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Citation: LI Jian-Xiao, MAO Zheng-Zhou, MEI Wen-Jie, WANG Zhao-Yang. Synthesis and Characterizations of Bisbenzimidazoles and Their Anti-cancer Activities[J]. Chinese Journal of Applied Chemistry, ;2010, 27(9): 1017-1020. doi: 10.3724/SP.J.1095.2010.90838 shu

Synthesis and Characterizations of Bisbenzimidazoles and Their Anti-cancer Activities

a. School of Chemistry and Environment, South China Normal University, Guangzhou 510006;
b. School of Chemistry and Chemical Engineeing, Guangdong Pharmaceutical University, Guangzhou 510006

Received Date: 11 December 2009
Revised Date: 20 January 2010

Using DMF as solvent,3,3'-diaminobenzidine and aromatic aldehydes as starting materials,and KI as catalyst,six new bisbenzimidazoles were synthesized in the presence of air.The structures of the compounds were characterized by means of FTIR,¹H NMR,¹³C NMR,MS and elemental analysis.The optimal synthetic conditions were investigated.When the temperature was 150℃ and the reaction time was 12 h,the six compounds were obtained with yields in the range of 58.4% to 98.0%.The new method with readily available catalyst is advantageous to conventional synthetic process of bisbenzimidazoles due to its less steps,simpler operations,easier post-processings and higher yields.The anti-tumor activities of the target compounds were preliminarily examined via MTT method on Bel-7402 cell in vitro,and they exhibited certain inhibition activities.
- bisbenzimidazoles,
- synthesis,
- characterization,
- anti-cancer activity
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