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Citation: TENG Han-Bing. Synthesis of N^ω-Hydroxy-nor-L-arginine[J]. Chinese Journal of Applied Chemistry, ;2010, 27(9): 1111-1113. doi: 10.3724/SP.J.1095.2010.90811 shu

Synthesis of N^ω-Hydroxy-nor-L-arginine

TENG Han-Bing

College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070

Received Date: 3 December 2009
Revised Date: 23 January 2010

The arginase inhibitor N^ω-hydroxy-nor-L-arginine dihydrochloride was successfully synthesized from N^α-Boc-L-glutamine precursor.The expensive reagent was not required in the synthetic process and a seven-step reaction was reduced to a three-step one.Not only was the separation procedure simplified,but also the total yield was increased from 21% to 37%.
- arginase inhibitor,
- amino-protecting,
- synthesis
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通讯作者: 陈斌, bchen63@163.com

Synthesis of N^ω-Hydroxy-nor-L-arginine