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Citation: ZHU Zheng-Hui, LEI Ze, JIANG Ming-Zhongd, MU Xiao-Yun, FU Zheng-Qi, WEN Xiao-Jiang, ZHU Hong-You. Structural Modification of the A-ring Baicalein[J]. Chinese Journal of Applied Chemistry, ;2010, 27(9): 1038-1041. doi: 10.3724/SP.J.1095.2010.90715 shu

Structural Modification of the A-ring Baicalein

a. Chemical Science and Engineering College of Yunnan University, Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan University, Kunming 650091;
b. Yiyang Enviromental Monitoring Station, Yiyang;
c. Yunnan University Medical Development Co., Ltd, Kunming 650222;
d. Yunnan Police Officer Academy, Kunming 650222

Received Date: 30 October 2009
Revised Date: 1 March 2010

Using baicalin,the main active component of a traditional Chinese herb Scutellaria baicalensis, and one of its derivative,6,7-diacetoxylbaicalein,as precursors,a series of C₈-substituted and di or tri-O-methylated baicalein derivatives was synthesized in good yields by iodination,nitration,reductive amination and selective methoxylation or hydrolysis of 6,7-diacetoxylbaicalein.The structures of these producrs were characterized.They featured with a broad spectrum of biological activities,notably anti-oxidant.
- baicalin,
- diacetoxylbaicalein,
- selective methoxylation,
- structural modification
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