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Citation: AN Lian-Ying, ZHANG Zhen-Guo, ZHAO Xian-Yin, LEI Ning, PEI Ling-Fang. Synthesis and Structural Characterization of Optical Pure (S)-Benzyl-2-(benzyloxycarbonylamino)-4-oxobutanoate[J]. Chinese Journal of Applied Chemistry, ;2010, 27(7): 863-865. doi: 10.3724/SP.J.1095.2010.90639 shu

Synthesis and Structural Characterization of Optical Pure (S)-Benzyl-2-(benzyloxycarbonylamino)-4-oxobutanoate

College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059

Received Date: 29 September 2009
Revised Date: 4 December 2009

(S)-Benzyl-2-(benzyloxycarbonylamino)-4-oxobutanoate was synthesized from L-methionine via methylation reaction,hydrolysis,carboxyl and amino protection,pyridinium chorochromate(PCC) oxidation. The structure of the target product was characterized by means of ¹H NMR,IR and MS. The optical purity was determined by HPLC and polarimeter method. The overall yield was 30.0%. The purity and ee value of the target compound were 99.3% and 99.5%,respectively.
- (S)-benzyl(benzyloxycarbonylamino) oxobutanoate,
- L-methionine,
- synthesis
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