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Citation: HU Yu-Feng, LUO Jun, LV Chun-Xu. Synthesis of Fluoroaromatics via Fluorodenitrations with Tetramethylammonium Fluoride[J]. Chinese Journal of Applied Chemistry, ;2010, 27(6): 669-672. doi: 10.3724/SP.J.1095.2010.90530 shu

Synthesis of Fluoroaromatics via Fluorodenitrations with Tetramethylammonium Fluoride

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094

Received Date: 11 August 2009
Revised Date: 24 October 2009

An efficient method for the synthesis of fluoroaromatics with tetramethylammonium fluoride(TMAF_anh.) as fluorination agent via the fluorodenitration reaction was reported.Fluoroaromatics were obtained from TMAF_anh. and nitroaromatics by simply stirring them together at 80~100℃ for 1~5 h in an anhydrous solution of DMF in 19.4%~99.0% yields.The nucleophilic fluorinating method has the advantages of mild reaction conditions,high yields,easy work-up and no phenol or ether side-products were detected in the reaction.
- tetramethylammonium fluoride,
- nitroaromatic,
- fluoroaromatic,
- fluorodenitration
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