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Citation: ZHANG Xiao-Ji, CUI Jian-Guo, LI Ying, FAN Jian-Chun. A Novel Method for Synthesis of 3β-Hydroxyandrost-4-en-6,17-dione[J]. Chinese Journal of Applied Chemistry, ;2010, 27(5): 615-617. doi: 10.3724/SP.J.1095.2010.90429 shu

A Novel Method for Synthesis of 3β-Hydroxyandrost-4-en-6,17-dione

Department of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001

Received Date: 29 June 2009
Revised Date: 28 August 2009

Dehydroepiandrosterone(1) was oxidized with pyridinium chlorochromate(PCC) to obtain androst-4-en-3,6,17-trione(2),which was then submitted to reduction with NaBH₄ in the presence of Co²⁺ to obtain 3β-hydroxyandrost-4-en-6,17-dione(3),a non-androgenic aromatase inhibitor.Compared with literature's methods,this method shortens the reaction steps and improves the reaction yield.The structure of compound 3 was characterized by NMR and IR.
- dehydroepiandrosterone,
- 3β-hydroxyandrost-en-dione,
- synthesis
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