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Citation: TAO Li-Minga, LIU Wen-Qia, TAN Nib, ZHOU Yun. Synthesis of 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one[J]. Chinese Journal of Applied Chemistry, ;2010, 27(4): 494-496. doi: 10.3724/SP.J.1095.2010.90420 shu

Synthesis of 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one

a. Department of Chemistry and Life Science, Xiangnan University, Chenzhou 423000;
b. School of Chemistry and Chemical Engineering, University of South China, Hengyang

Received Date: 24 June 2009
Revised Date: 6 August 2009

5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one was synthesized via the acylation reaction and iodocyclization reaction and Suzuki cross-coupling reaction with 2-(methylthio)aniline as the initial material.Effects including catalysts on acylation reaction,solvents on iodocyclization and catalysts,ligand,base and reaction temperature on Suzuki cross-coupling reaction have been investigated.Under optimum conditions,the yield of the product was up to 68.5%.The chemical structures of the intermediates and target product were characterized by IR,NMR and MS spectra.
- methyldiphenylbenzothiazepin-4(5H)-one,
- acylation reaction,
- iodocyclization,
- Suzuki cross-coupling reaction
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