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Citation: LI Li-Li, ZHOU Wen-Hui, LI Yong, LIN Li-Ming, ZHU Xiao-Bin, YANG Huang-Hao, WANG Xiao-Ru. Synthesis of Domoic Acid Imprinted Polymer and Its Extraction Application[J]. Chinese Journal of Applied Chemistry, ;2010, 27(2): 132-136. doi: 10.3724/SP.J.1095.2010.90114 shu

Synthesis of Domoic Acid Imprinted Polymer and Its Extraction Application

a. Institute of Oceanology, CAS, Qingdao 266061;
b. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266061;
c. The First Institute of Oceanography, SOA, Qingdao 266061;
d. Technological Center, Shandong Entry-Exit Inspection & Quarantine Bureau, Qingdao 266061

Received Date: 19 February 2009
Revised Date: 21 May 2009

Domoic acid(DA) was used as the target compound,its structural analog 1,3,5-pentanetri-carboxylic acid was used as template molecules,4-vinyl pyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linking agent for the preparation of the molecularly imprinted polymers(MIPs). After Soxhlet extraction of the template 1,3,5-pentanetricarboxylic acid,binding sites were formed in the polymer with complementary size,shape,and positioning of chemical functionalities to 1,3,5-pentanetricarboxylic acid and also structural analog domoic acid. The molecularly imprinted polymer was investigated with the aid of equilibrium binding experiments to evaluate the molecular recognition and binding characteristics of the imprinted polymer. The results show that compared with non-imprinted polymer,the imprinted polymer exhibits a much higher affinity for domoic acid. The molecularly imprinted solid-phase extraction(MISPE) columns were prepared from a 1.0 mL glass syringe packed with 150 mg of the molecularly polymer. The MISPE procedure performed in an off-line mode coupled with reversed-phase high performance liquid chromatography was developed to extract domoic acid from Mytilus edulis and seawater samples. The mean recoveries of domoic acid from Mytilus edulis and artificial seawater spiked with 2 mg/L domoic acid were (93.4±4.9)% and (89.7±3.2)%(n=3),respectively.
- domoic acid,
- molecularly imprinted polymer,
- amnesia shellfish poisoning(ASP),
- solid-phase extraction
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Synthesis of Domoic Acid Imprinted Polymer and Its Extraction Application

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com