Citation: TIAN Geng, SUN Wen-Bo, LU Le-Hui. Polydopamine-modified FeSe₂ Nanoparticles for Magnetic Resonance Imaging-guided Photothermal Therapy of Tumors[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 833-841. doi: 10.19756/j.issn.0253-3820.221643 shu

Polydopamine-modified FeSe₂ Nanoparticles for Magnetic Resonance Imaging-guided Photothermal Therapy of Tumors

TIAN Geng ^1,2 ,
SUN Wen-Bo ^1,, ,
LU Le-Hui ^1,2,,

1.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: SUN Wen-Bo, LU Le-Hui,
Received Date: 29 December 2022
Revised Date: 21 March 2023

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22134006, 21721003, U2241287).

Designing and preparing multifunctional nanomaterial is a hot research topic in tumor diagnosis and treatment. In this study, polydopamine-modified iron diselenide (FeSe₂) nanoparticles (FeSe₂-PDA NPs) were constructed for magnetic resonance imaging (MRI) and photothermal therapy of tumors. The FeSe₂-PDA NPs were prepared by modifying polydopamine on the surface of FeSe₂ NPs prepared by liquid-phase synthesis, and their morphological, optical and magnetic properties were investigated. Based on the excellent biocompatibility, their MRI effect and MRI-guided photothermal treatment of tumors were investigated in mouse experiments in vivo. The results showed that the relaxivity (r₂) of FeSe₂-PDA NPs was 129.47 L/(mmol·s), which could significantly reduce the T₂ signal of MRI. Meanwhile, the cell survival rate was about 10% after 808 nm laser irradiation due to the excellent absorption ability in the near-infrared region. In the in vivo experiments of tumor-bearing mice, the tumor disappeared without recurrence within 14 days after photothermal ablation. The results showed that the synthesized FeSe₂-PDA NPs had great potential in MRI diagnosis of tumors and photothermal therapy.
- Magnetic resonance imaging,
- Photothermal therapy,
- Polydopamine,
- Iron diselenide,
- Theranostic agent
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Polydopamine-modified FeSe₂ Nanoparticles for Magnetic Resonance Imaging-guided Photothermal Therapy of Tumors