Citation: FENG Yan-Jun, JIAO Xiao-Mei, WANG Ze, ZHAO Ya-Qi, HUO Shu-Hui, ZHAO Ai-Juan, WANG Zhi-Zhou, LU Xiao-Quan. ZnO@Cys Multi-pathway Synergistic Enhanced Tetracarboxyphenyl Porphyrin Electrochemiluminescence for Analysis of Uric Acid[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 851-859. doi: 10.19756/j.issn.0253-3820.221640 shu

ZnO@Cys Multi-pathway Synergistic Enhanced Tetracarboxyphenyl Porphyrin Electrochemiluminescence for Analysis of Uric Acid

Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: LU Xiao-Quan, luxq@nwnu.edu.cn
Received Date: 27 December 2022
Revised Date: 23 March 2023

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22174110, 22127803), the Special Fund Project for Guiding Local Scientific and Technological Development by the Central Government (No. 2020-2060503-17), the Industrial Support Plan of Gansu Provincial Department of Education (No. 2021cyzc-01) and the Innovation Fund Project for Higher Education of Gansu Province (No. 2021A-187).

Uric acid (UA), as a typical small biological molecule, is an important antioxidant that helps maintain blood pressure. However, abnormal UA concentration can cause gout, metabolic syndrome and cardiovascular diseases. A quick and sensitive test for UA is crucial for diagnosis of these diseases. In this study, TCPP-ZnO@Cys composite was prepared by acylation of zinc oxide (ZnO) modified with tetracarboxyphenyl porphyrin (TCPP) and L-cysteine (L-cysteine). ZnO@Cys, as a co-reactant, could promote S₂O₈^2- to produce more SO₄^.-, and catalytically induced H₂O to produce an appropriate amount of OH·. It could also promote the generation of SO₄^.-. The electrochemiluminescence (ECL) strength of TCPP was enhanced by synergistic action of multiple pathways. The redox reaction between UA and K₂S₂O₈ consumed SO₄^.- in the system, which would quench the ECL signal. Based on these, a detection platform for UA was successfully constructed. The ECL intensity of the system had a linear relationship with concentration of UA in the range of 2.4-48.0 μmol/L. The linear equation was y=5170.7 lgC_UA - 1049.1, and the detection limit was 0.63 μmol/L (3σ). The established detection platform realized highly sensitive detection of UA.
- Electrochemiluminescence,
- Carboxyl-porphyrin,
- Cysteine,
- Coreactive accelerator,
- Amidation reaction
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