Citation: HU Zhen-Zhen, LI Xiao-Tong, LI Xiao-Dong, ZHANG Hua, LIU Gui-Feng, WANG Zhen-Xin. Applications of Peptide Functionalized Gold Nanoparticles in Bioanalysis and Biomedicine[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 681-694. doi: 10.19756/j.issn.0253-3820.221631 shu

Applications of Peptide Functionalized Gold Nanoparticles in Bioanalysis and Biomedicine

1.
Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China;
2.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
3.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China

Corresponding author: LIU Gui-Feng, WANG Zhen-Xin,
Received Date: 21 December 2022
Revised Date: 14 February 2023

Fund Project: Supported by the Jilin Provincial Science and Technology Department (No. 20220203113SF), the National Natural Science Foundation of China (Nos. 52275006, 21974133) and the Wu Jieping Medical Foundation (No. 320.6750.19089-40).

The functionalization of gold nanoparticle (GNP) surface with specific ligand is helpful to improve the bioanalysis performance of GNP and realize special application of GNP in biomedicine. Because it is easy to integrate various functions including specific biorecognition and therapeutic function into one sequence, peptides become one of the most common ligands for functionalization of GNP. The peptide functionalized GNPs (GNP@peptides) have been extensively used to build biosensing nanoplatforms with high sensitivity and selectivity for detecting various analytes (such as heavy metal ions, biomarkers, etc.) and novel therapeutic/drug delivery nanosystems with excellent anti-tumor and/or antibacterial capabilities. This review provided an overview of the effect of GNP@peptides on the precision diagnostics and therapy of diseases, and discussesed the current challenges and future prospects of GNP@peptide-based biosensing nanoplatforms and nanomedicines in practical applications.
- Peptide ligand,
- Gold nanoparticles,
- Biosensing nanoplatforms,
- Nanomedicines,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142