Citation: ZHANG Yu, SONG Zhi-Min, DU Yan. Recent Progress of Nanozyme-Based Sensors in Point-of-Care Testing[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(5): 800-810. doi: 10.19756/j.issn.0253-3820.221610 shu

Recent Progress of Nanozyme-Based Sensors in Point-of-Care Testing

ZHANG Yu ^1,2 ,
SONG Zhi-Min ^1,2 ,
DU Yan ^1,2,,

1.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
School of Applied Chemistry and Engineering, University of Science & Technology of China, Hefei 230026, China

Corresponding author: DU Yan, duyan@ciac.ac.cn
Received Date: 10 December 2022
Revised Date: 17 February 2023

Fund Project: Supported by the National Natural Science Foundation of China (No. 22174137), the Key Research and Development Project of Jilin Scientific and Technological Development Program (Nos. 202102041266YY, 20230204113YY) and the Changchun Municipal Science and Technology Bureau Special Project on Scientific and Technological Innovation Cooperation (No. 22SH13).

Point-of-care testing (POCT) is rapid, portable and accurate, which can break the limitations of space, large and expensive instruments, professional technicians, and long-time consumption. In recent years, a large number of methods, especially those involving signal conversion strategies, have been developed to construct sensitive and rapid sensors based on commercial POCT devices. These sensors are widely used in disease diagnosis, health management, environmental monitoring, and emergency response analysis. With the advantages of high stability, low cost, simple preparation and diverse enzyme-mimicking activities, nanozyme can flexibly engage in the construction of sensors toward different targets, where commercial POCT devices are used as readouts. This review highlighted the recent progress of nanozyme-based sensors in POCT, and sum up several readout signal types including color, pressure, temperature, pH, glucose and electrochemistry. Finally, the limitations of nanozyme-based sensors were discussed and the direction in the future development is prospected.
- Nanozyme,
- Sensor,
- Point-of-care testing,
- Portable device,
- Review
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