Citation: SONG Hui-Jia, WANG Xing-Yan, LI Ze-Hong, GAO Rui-Xia. Construction of Boric Acid Affinity Magnetic Molecularly Imprinted Polymer and Its Application in Selective Extraction of Rutin[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 600-610. doi: 10.19756/j.issn.0253-3820.221587 shu

Construction of Boric Acid Affinity Magnetic Molecularly Imprinted Polymer and Its Application in Selective Extraction of Rutin

School of Chemistry, Xi'an Jiaotong University, Xi'an 710049, China

Corresponding author: GAO Rui-Xia, ruixiagao@xjtu.edu.cn
Received Date: 29 November 2022
Revised Date: 12 January 2023

Fund Project: Supported by the Natural Science Foundation of Shaanxi Province, China (Nos. 2020JM-066, 2020JQ-019).

Molecularly imprinted polymers (MIPs), known as ″artificial antibodies″, are widely used in extraction and separation of natural pharmaceutical active ingredients due to the high selectivity. To enhance the extraction efficiency and the affinity of imprinted pores for target molecules, a novel type of boronic acid-affinity magnetic molecularly imprinted polymers (RT-PBA/MMIPs) was prepared using phenylboronic acid (PBA)-modified magnetic spheres (PBA/MSN) as the carrier, RT as the template molecule, and dopamine (DA) as the functional monomer, while boronic acid affinity and two-step template immobilization strategies were synergistically applied at the same time. Through a series of physical and chemical characterizations, it was verified that the prepared RT-PBA/MMIPs had uniform particle size, stable crystal form, and excellent magnetic properties. Meanwhile, kinetic, thermodynamic and selective adsorption experiments demonstrated that RT-PBA/MMIPs had fast adsorption speed (6 min to reach adsorption equilibrium), high adsorption capacity (Q=2.04 mg/g), and good selectivity (IF=2.43) and reusability (the adsorption efficiency was higher than 94.43% after 6 adsorptiondesorption cycles). In addition, RT-PBA/MMIPs were used as a solid-phase extraction adsorbent in combination with high performance liquid chromatography to achieve efficient extraction and enrichment of RT from Sophora japonica with recoveries of 83.1%-92.3%. In a word, the developed RT-PBA/MMIPs showed good practical application prospects and were expected to be used for the rapid and selective separation and extraction of RT as well as other active ingredients of natural medicines.
- Boronic acid affinity,
- Two-step template immobilization,
- Magnetic surface molecularly imprinted polymers,
- Specific recognition,
- Rutin
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