Citation: SUN Zhi-Yuan, FAN Wen-Fang, WANG Yong, ZHUANG Qian-Fen. Poly(neutral red)/Multi-walled Carbon Nanotube Composite Modified Electrochemical Sensor for Ratiometric Detection of Estriol[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(1): 42-52. doi: 10.19756/j.issn.0253-3820.221543 shu

Poly(neutral red)/Multi-walled Carbon Nanotube Composite Modified Electrochemical Sensor for Ratiometric Detection of Estriol

School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China

Corresponding author: ZHUANG Qian-Fen, qfzhuang@ncu.edu.cn
Received Date: 3 November 2022
Revised Date: 23 November 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos.31960495, 32160600, 21864017).

A poly(neutral red)/multi-walled carbon nanotube nanocomposite modified electrochemical sensor was established for ratiometric sensing of estriol. The poly(neutral red) was used as the internal reference electroactive probe, and the oxidation peak current ratio of estriol to poly(neutral red) was used for accurate quantitative detection of estriol. The poly(neutral red)/multi-walled carbon nanotube nanocomposite was demonstrated good electroconductivity and high electrocatalytic performance which could improve the detection sensitivity. The response of the ratiometric sensor was linearly proportion to the estriol concentration in the 0.1-2.0 μmol/L range, with a limit of detection (S/N=3) of 0.08 μmol/L. The electrochemical oxidation reaction of estriol on the poly(neutral red)/multiwalled carbon nanotube nanocomposite/glassy carbon electrode was demonstrated to undergo a two-electron/two-proton process. Moreover, the sensor had high sensitivity, strong anti-interference ability and good stability, and was successfully applied to testriol analysis in pharmaceutical cream, urine and lake water samples.
- Estriol,
- Poly(neutral red),
- Ratiometric sensor,
- Electrochemistry
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