Citation: LI Li, LI Meng, YANG Ming-Li, LI Hong-Lei, ZHANG Huan, MA Yue, LIN Le-Er, ZHANG Ming. Selective Detection of Calcium Folinate by Fluorescence Quenching of Nitrogen and Phosphorus Codoped Carbon Nanoparticles[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(2): 296-304. doi: 10.19756/j.issn.0253-3820.221407 shu

Selective Detection of Calcium Folinate by Fluorescence Quenching of Nitrogen and Phosphorus Codoped Carbon Nanoparticles

LI Li ^1,, ,
LI Meng ² ,
YANG Ming-Li ¹ ,
LI Hong-Lei ¹ ,
ZHANG Huan ¹ ,
MA Yue ¹ ,
LIN Le-Er ¹ ,
ZHANG Ming ^1,,

1.
Kangda College, Nanjing Medical University, Lianyungang 222000, China;
2.
Department of Thoracic Surgery, The Second People's Hospital of Lianyungang, Lianyungang 222000, China

Corresponding author: LI Li, ZHANG Ming,
Received Date: 9 August 2022
Revised Date: 11 December 2022

Fund Project: Supported by the Jiangsu Overseas Research & Training Program for University Prominent Young & Middle-aged Teachers and Presidents Fund, the Qing Lan Project Fund of Jiangsu Province (No. KD2021qljs001), the Science and Technology Project Fund of Gaoxin District in Lianyungang (No. HZ201906), the Petrel Plan Project Fund of Lianyungang (No. 2020-QD-005), the Innovation and Entrepreneurship Training Program for College Students in Jiangsu Province (Nos. 202113980012Y, 202113980014Y) and the Science and Technology Funds of Kangda College of Nanjing Medical University (Nos. KD2020KYJJZD074, KD2021KYJJZD014, KD2021KYRC003, KD2021KYRC015).

Nitrogen and phosphorus codoped carbon nanoparticles (N/P-CNPs) were synthesized by one-step hydrothermal method using ammonium phosphate and sodium ascorbate as raw materials, with a quantum yield of 19%. Based on the rapid and highly selective quenching of N/P-CNPs by calcium folinate (CF), a new method for quantitative determination of CF in CF injection samples was established. Under the optimal experimental conditions, the concentration of CF in the range of 0.2-108.5 μmol/L and the degree of fluorescence quenching of N/P-CNPs ((F₀-F)/F₀, F₀ is the initial fluorescence intensity, F is the fluorescence intensity after adding CF) showed a good linear relationship. The detection limit was 0.05 μmol/L. Besides, it was verified that the fluorescence quenching mechanism of CF on N/P-CNPs was inner filter effect and static quenching effect. The established method was used to detect the content of CF in actual samples, and the obtained results were basically consistent with the results of high performance liquid chromatography, indicating that the method had good practicability and provided a new strategy for the detection of CF.
- Nitrogen and phosphorus codoping,
- Carbon nanoparticles,
- Fluorescence,
- Calcium folinate,
- Inner filter effect,
- Static quenching
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