Citation: LIU Yu-Long, SHAO Zhi-Guo, ZHANG Xiao-Fei, LIU Guang-Quan. Determination of Volatile Organic Compounds in Complex Matrix Waters by Headspace-Gas Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 589-599. doi: 10.19756/j.issn.0253-3820.221387 shu

Determination of Volatile Organic Compounds in Complex Matrix Waters by Headspace-Gas Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry

LIU Yu-Long ^1,2,, ,
SHAO Zhi-Guo ^1,2 ,
ZHANG Xiao-Fei ^1,2 ,
LIU Guang-Quan ^1,2

1.
State Key Laboratory of Petroleum Pollution Control, Beijing 102206, China;
2.
Research Institute of Safety and Environment Technology, China National Petroleum Corporation, Beijing 102206, China

Corresponding author: LIU Yu-Long, liuyulong98@cnpc.com.cn
Received Date: 29 July 2022
Revised Date: 10 December 2022

Fund Project: Supported by the Scientific Research and Technology Development Project of China National Petroleum Corporation (No. 2021DJ6605).

A headspace-gas chromatography-quadrupole/orbitrap high resolution mass spectrometry (HS-GC-Q/OrbitrapHRMS) for determination of 56 kinds of volatile organic compounds (VOCs) in complex matrix waters was developed. By optimizing the conditions of injection delay time of headspace injector and inlet temperature of gas chromatograph, the sample condensation of high-boiling analytes inside the syringe's needle was eliminated. A TG-5SILMS chromatographic column was used for separation, the data were collected by electron ionization (EI) sources under the full scan mode, and the analytes were quantified by using dichloromethane-D₂ and fluorobenzene as internal standards. In a 10-mL test sample, sodium chloride (NaCl) concentration was 30% (m/V) and methanol concentration should be below 3% (V/V). The calibration curves of 56 compounds showed good linearity in the concentration ranges of 0.2-10 μg/L (R²>0.998) and 10-200 μg/L (R²>0.995). The recoveries ranged from 83.5% to 129.0% at three spiked levels (2, 10 and 100 μg/L), while the relative standard deviations (RSD) ranged from 0.4% to 13.0%. The limits of detection and limits of quantification were 0.01-0.17 μg/L and 0.05-0.69 μg/L, respectively. In the 99% confidence interval, the measurements of reference material (RM) of VOCs in groundwater with high bicarbonate and natural organic matter showed that there was no significant difference among the results of this method and those of the RM's property values. The detection method with high sensitivity and precision was superior to the current detection methods, and suitable for determining VOCs in water samples which could not introduce to GC-MS system by P&T samplers.
- Gas chromatography-quadrupole/orbitrap high resolution mass spectrometry,
- Headspace,
- Volatile organic compounds,
- Dichloromethane-D₂
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