Citation: WANG Chuang, QIN Lu-Yuan, LI Dong-Mei, XUE Jin-Juan, GUO Lei, TANG Li. Application Advance of Nanomaterials in Laser Desorption/Ionization Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(2): 172-183. doi: 10.19756/j.issn.0253-3820.221328 shu

Application Advance of Nanomaterials in Laser Desorption/Ionization Mass Spectrometry

WANG Chuang ^1,2 ,
QIN Lu-Yuan ² ,
LI Dong-Mei ^2,3 ,
XUE Jin-Juan ² ,
GUO Lei ^2,, ,
TANG Li ^1,,

1.
Key Laboratory of Ethnicmedicine, College of Pharmacy, Minzu University of China, Beijing 100081, China;
2.
State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, China;
3.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

Corresponding author: GUO Lei, TANG Li,
Received Date: 2 July 2022
Revised Date: 18 August 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 21974152, 81873397, 22104149).

Nanomaterial-based laser desorption/ionization mass spectrometry (LDI-MS) technique has emerged and bloomed in recent years. Taking the advantages of nanomaterials, including high laser desorption and transfer efficiency, large specific surface area, and inert ionization, LDI-MS owned the cutting-edge advances such as high sensitivity, speediness, high throughput, and clean spectrum background. This review summarizes the application advances of nanomaterials in LDI-MS in biomedical analysis over the past 10 years, categorized by carbon-based nanomaterials, silicon-based nanomaterials, metal-organic frameworks, covalent organic frameworks, and metalbased nanomaterials. It compares the influence of different functionalization or composite material on the issues containing sensitivity and analyte kinds, and briefly illustrates the application of various nanomaterials on mass spectrometric imaging techniques that focuses on the applicability of the spatial distribution of internal and external metabolites. Finally, the key issues and prospects of this field are depicted.
- Laser desorption/ionization mass spectrometry,
- Matrix,
- Nanomaterials,
- Biomedical samples,
- Mass spectrometric imaging,
- Review
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