Citation: YANG Qi, LI Ken-Ken, WEI Pei-Yuan, NIU Zi-Jun, WANG Wen-Wen, LIU Li, WANG Song-Lei. Sensitive Detection of Clenbuterol by Electrochemical Sensor Based on N-doped Cobalt Metal Organic Framework Modified Electrode[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 559-569. doi: 10.19756/j.issn.0253-3820.221297 shu

Sensitive Detection of Clenbuterol by Electrochemical Sensor Based on N-doped Cobalt Metal Organic Framework Modified Electrode

College of Food and Wine, Ningxia University, Yinchuan 750021, China

Corresponding author: WANG Song-Lei, wangsonglei163@126.com
Received Date: 18 June 2022
Revised Date: 1 March 2023

Fund Project: Supported by the National Natural Science Foundation of China (No. 31660484) and the Project of Ningxia Excellent Youth Science Foundation (No. 2022AAC05022).

N-doped cobalt metal organic framework (N-Co-MOF) was synthesized by solvothermal method using trimesic acid as ligand and Co²⁺ and polyvinyl pyrrolidone (PVP) as central metal ions and nitrogen source. The morphology and composition of the materials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). The electrochemical sensor for detection of clenbuterol (CLB) was constructed on glassy carbon electrode (GCE) modified with N-Co-MOF. The cyclic voltammetry (CV) characterization results showed that the N-Co-MOF could provide more electrochemical active sites and significantly improve the electron transfer ability, and had good electrocatalytic oxidation activity for CLB. The linear range of the sensor for CLB was 0.01-29.5 μmol/L, and the detection limit (3σ) was 4.6 nmol/L. The sensor had excellent anti-interference performance, good reproducibility and stability, and had good accuracy in detection of CLB in actual meat samples, with recoveries of 98.5%-102.9%.
- Electrochemical sensor,
- Clenbuterol,
- Polyvinyl pyrrolidone,
- Metal organic framework,
- Cyclic voltammetry
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