Citation: ZHAN Feng-Ping, WU Yang-Yi, DAI Xiao-Hui, LIANG Chao, GAO Feng, WANG Qing-Xiang. Construction and Application of Fe(Ⅲ)-2-Aminoterephthalic Acid Metal-Organic Framework-based Label-free Chloramphenicol Electrochemical Sensor[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 539-548. doi: 10.19756/j.issn.0253-3820.221149 shu

Construction and Application of Fe(Ⅲ)-2-Aminoterephthalic Acid Metal-Organic Framework-based Label-free Chloramphenicol Electrochemical Sensor

1.
Fujian Provincial Key Laboratory of Modern Analytical Science and Separation Technology, Department of Chemistry and Environment Science, Minnan Normal University, Zhangzhou 363000, China;
2.
Zhangzhou Products Quality Supervision Institute, Zhangzhou 363000, China

Corresponding author: WANG Qing-Xiang, axiang236@vip.163.com
Received Date: 28 March 2022
Revised Date: 21 October 2022

Fund Project: Supported by the National Natural Science Foundation of China (No. 21802064), the Natural Science Foundation of Fujian Province (Nos. 2021J01989, 2022J01899) and the Science and Technology Project of Fujian Administration for Market Regulation (No. FJMS2020048).

The development of rapid and simple electrochemical sensing technology for detection of chloramphenicol (CAP) has important application prospects in food safety and environmental monitoring. Herein, NH₂-MIL-88(Fe) was successfully synthesized by a hydrothermal method using FeCl_3∙·6H₂O and 2-aminoterephthalic acid (2-ATPA) as the starting materials. Then, the NH₂-MIL-88(Fe) was covalently anchored on the surface of carboxylated glassy carbon electrode through the amino group on 2-ATPA. Furthermore, the 5'-PO₄^3- modified chloramphenicol aptamer (C-Apt) was self-assembled on the NH₂-MIL-88(Fe) surface through the coordination between -PO₄^3- and Fe³⁺ to construct a novel label-free electrochemical biosensing interface. The immobilization of C-Apt did not need any crosslinking agent or pre-treatment. Electrochemical assays showed that the NH₂-MIL-88(Fe) modified electrode had strong catalytic activity for 3,3',5,5'-tetramethylbenzidine (TMB)/H₂O₂ system due to the nano enzymetic activity of NH₂-MIL-88(Fe); while the catalytic activity could be inhibited after forming a barrier layer that generated by the capture of CAP by C-Apt, through which the target CAP could be detected through the label-free method. The quantitative analysis results showed that the catalytic current (I_p) for the oxidation of TMB/H₂O₂ system had a good linear relationship with the negative logarithm of CAP concentration (-lgC) within the concentration range of 1.0 pmol/L -0.1 μmol/L, and the detection limit was as low as 330 fmol/L (S/N=3). The biosensor could be used for detection of CAP residue in actual milk samples, which provided a new idea for the rapid detection of CAP residue in the food field.
- NH₂-MIL-88(Fe),
- Label-free,
- Electrochemical sensor,
- Nanozyme,
- Chloramphenicol residue
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沈阳化工大学材料科学与工程学院沈阳 110142