Citation: ZOU Zhi-Feng, GAO Jing, LAI Yi, XU Zhi-Ai. Tumor-Targeted Theranostic Probe for Near Infrared Ⅱ Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(6): 912-923. doi: 10.19756/j.issn.0253-3820.221115 shu

Tumor-Targeted Theranostic Probe for Near Infrared Ⅱ Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer

ZOU Zhi-Feng ^1,2 ,
GAO Jing ² ,
LAI Yi ² ,
XU Zhi-Ai ^1,,

1.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China;
2.
State Key Laboratory of Drug Research&Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Corresponding author: XU Zhi-Ai, zaxu@chem.ecnu.edu.cn
Received Date: 8 March 2022
Revised Date: 20 April 2022

Fund Project: Supported by the National Natural Science Foundation of China(No. 22074043).

Donor-acceptor-donor(D-A-D) type fluorescent probes have been widely used in biological imaging due to their excellent optical stability and biocompatibility. By molecular engineering, the fluorescence emission of D-A-D type probe can shift to the near infrared Ⅱ window(NIR-Ⅱ), which shows that the probe has potential for bioimaging and photothermal therapy due to its good photothermal conversion efficiency. However, its large molecular weight leads to unavoidable disadvantages such as poor water solubility, which seriously limits its application. Therefore, in this work, an actively targeted polymer(CRGDK-PEG-b-PLGA) was designed to improve the water-solubility, tumor-specificity and photothermal efficacy of D-A-D type fluorescent probe(TQTCD), thus achieving the integration of diagnosis and treatment. CRGDK-PEG-b-PLGA and TQTCD could self-assemble to form homogeneous and stable nanoparticles(named RPP@TQTCD). This strategy did not affect the fluorescence properties and photothermal effects of TQTCD. CRGDK ligand-modification could increase the tumor accumulation of RPP@TQTCD NPs and interact with the Neuropilin-1(NRP-1) receptor, which was highly expressed on the surface of tumor cells, to promote cellular uptake of RPP@TQTCD NPs through NRP-1-CRGDK pathway.Then, RPP@TQTCD NPs could effectively kill tumor cells under 808 nm laser irradiation in vitro and in vivo. This study provided an effective strategy for the diagnosis and photothermal treatment of triple negative breast cancer(TNBC) through the targeted delivery of hydrophobic probe.
- Active targeting,
- Near infrared Ⅱ region fluorescence,
- Photothermal therapy,
- Theranostic,
- Triple negative breast cancer
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