Citation: JIANG Jin-hua, CONG Ao-bo, WANG Yue-kun, BIAN Chao, LI Yang, TONG Jian-hua. Research on Charged Particle Microfluidic Enrichment Chip Based on Ion Exchange Membrane with Trigeminal Structure[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(4): 585-592. doi: 10.19756/j.issn.0253-3820.221077 shu

Research on Charged Particle Microfluidic Enrichment Chip Based on Ion Exchange Membrane with Trigeminal Structure

JIANG Jin-hua ^1,2 ,
CONG Ao-bo ^1,2 ,
WANG Yue-kun ^1,2 ,
BIAN Chao ¹ ,
LI Yang ¹ ,
TONG Jian-hua ^1,,

1.
State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China;2 School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: TONG Jian-hua, jhtong@mail.ie.ac.cn
Received Date: 16 February 2022
Revised Date: 13 March 2022

Fund Project: Supported by the National Key Research and Development Project of China(No. 2020YFB2009001)the National Natural Science Foundation of China(Nos. 61771451, 62071455)

Preconcentration is an effective method to detect trace biochemical substances. In this work, a microfluidic enrichment chip based on ion exchange membrane with trident structure was developed for both the detection of charged particles in water environment and the enrichment of anions based on the principle of ion concentration polarization. The chip was fabricated by 3D printing and micro-nano processing technology. By controlling the potential difference between enrichment zone and buffer zone, the electroosmotic force and repulsion force could be controlled to obtain a stable depletion zone and enrichment zone. In the enrichment experiment, when the negatively charged sodium fluorescein was used as the enrichment object, the factors affecting the enrichment factor such as voltage and enrichment time were explored, and the enrichment effect was verified in the concentration range of 0.2-3.0 μmol/L. The study showed that the trident ion exchange membrane could effectively avoid the permeation of the solution in the enrichment zone and buffer zone as experimental results, which greatly improved the enrichment factor. The enrichment factor of different concentrations of sodium fluorescein on this chip was close, and the highest was 102 times, which meant that the chip had the ability of enriching anions.
- Preconcentration,
- Ion concentration polarization,
- Microfluidic chip,
- Trifurcation,
- Ion exchange membrane
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