Citation: FANG Tian-Shu, NIU Ji-Cheng, XU Bei-Duo, ZHANG Yue, LI Li, LI Fei. Research Progress of Portable Point-of-Care Testing Technologies and Applications for Ocular Surface[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(11): 1639-1660. doi: 10.19756/j.issn.0253-3820.221061 shu

Research Progress of Portable Point-of-Care Testing Technologies and Applications for Ocular Surface

FANG Tian-Shu ^1,2 ,
NIU Ji-Cheng ^1,2 ,
XU Bei-Duo ^1,2 ,
ZHANG Yue ³ ,
LI Li ^3,, ,
LI Fei ^1,2,,

1.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China;
2.
Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China;
3.
Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Corresponding author: LI Li, LI Fei,
Received Date: 31 January 2022
Revised Date: 20 May 2022

Fund Project: Supported by the Natural Science Foundation of Shannxi Province, China (No.2020JC-06) and the Key R&D Plan of Shaanxi Province, China (Nos.2021SF-168, 2020ZDLSF02-06).

As a human visual organ, the outermost ocular surface tissue and its tear film contain a lot of information that can be used for disease diagnosis. Point-of-care testing (POCT) of physiological and biochemical indexes of ocular surface is of great importance for early diagnosis and long-term monitoring of chronic diseases, such as eye diseases and diabetes. In recent years, with the rapid development of biomaterials, micro- and nano-electronics and other technologies, POCT and portable sensing technologies for various physiological and biochemical indexes on the ocular surface have rapidly developed. This paper mainly reviews the research progress of portable POCT technologies and their applications on ocular surface in recent 5 years. Firstly, the main physiological and biochemical indexes of ocular surface related to eye and other diseases are introduced. Then, according to the detection platform and detection method, the paper-based and smart contact lens-based portable POCT platforms and the optical, electrochemical, electrical and microfluidic POCT methods for ocular surface are introduced, respectively. And the representative examples of portable POCT technologies of the physiological and biochemical indexes of ocular surface in recent 5 years are introduced. Finally, the challenges and future development direction of portable POCT technologies and devices on ocular surface are proposed. The objective of this paper is to introduce the portable POCT technologies and applications for ocular surface, so as to provide references for the development of diagnosis and treatment of ocular and related diseases.
- Ocular surface,
- Point-of-care testing,
- Portable,
- Paper-based platform,
- Smart contact lens
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沈阳化工大学材料科学与工程学院沈阳 110142