Citation: XU Lin-long, JIN Zhi-ming, FAN Yi-qiang. Research Progress and Application of Microneedle and Microfluidics Integration[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(4): 506-515. doi: 10.19756/j.issn.0253-3820.221017 shu

Research Progress and Application of Microneedle and Microfluidics Integration

School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology， Beijing 100029, China

Corresponding author: FAN Yi-qiang, fanyq@mail.buct.edu.cn
Received Date: 11 January 2022
Revised Date: 21 March 2022

In recent years, microneedles have been widely used in the fields of medical biological diagnosis, such as sampling and detection, transdermal drug delivery, etc, because of its painless and convenient advantages. Microfluidic chip is used to control micro-fluid, which has the advantages such as less reagent loss, fast detection speed and sensitive detection, etc. It is also popular in biochemical analysis, environmental science and other fields. The development of microfluidic chips and microneedles in the early stage is relatively independent. With the wide application of microfluidic chips and microneedles in biomedicine and other fields and the emergence of advanced micromachining methods such as 3D printing, in recent years, microneedles and microfluidic chips show a trend of combined application. For example, micro-fluidic channels are added on the surface or inside of the micro-needle to realize accurate sampling or drug delivery, or micro-needles are embedded inside the micro-fluidic chip to realize accurate control of droplet generation. Although the combination of microneedles and microfluidic chips can be widely used in subcutaneous sampling, drug transportation, medical diagnosis and other fields, it is still unclear how to realize the integrated preparation and application of microneedles and microfluidic chips. In this paper, the combined application of microneedles and microfluidic chips at home and abroad in recent years is reviewed, the method system of the combined application of microfluidic chips and microneedles is summarized, and the development trend of the combined application of microneedles and microfluidic chips in the future is prospected.
- Microneedles,
- Microfluidic chips,
- Integrated fabrication,
- Biomedical diagnosis,
- Review
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