Citation: LI Xia, CHEN Zhuang-Zhuang, FAN Ai-Hua, ZHANG Li-Li, SHAO Hui-Bo. Accumulation of Paracetamol on Surface of Simulated Cell Membrane Promoted by Hydrogen Bonding[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(9): 1364-1372. doi: 10.19756/j.issn.0253-3820.221012 shu

Accumulation of Paracetamol on Surface of Simulated Cell Membrane Promoted by Hydrogen Bonding

School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China

Corresponding author: SHAO Hui-Bo, hbs@bit.edu.cn
Received Date: 8 January 2022
Revised Date: 3 April 2022

Fund Project: Supported by the National Natural Science Foundation of China (No.21872006).

The widely used paracetamol (acetaminophen, APAP) for antipyretic and analgesic promoting enrichment on the cell membrane surface by means of hydrogen bonds is very important. In this work, 3-mercaptopropionic acid self-assembled monolayer (MPA SAM) containing hydrogen acceptors (negatively charged carboxylates) on the surface was used as simplified model to simulate the cell membrane surface. The enrichment of APAP promoted by hydrogen bonds on the surface of simulated cell membranes was studied by scanning electrochemical microscopy (SECM). The experimental results showed that with the increase of Mg²⁺ concentration or pH value, the carboxyl groups of MPA SAM dissociated and shifted positively to produce more carboxylates (hydrogen acceptors). The enrichment of APAP on the surface of MPA SAM was promoted. Furthermore, SECM image mode realized the visualization of enrichment. This work might provide a certain reference for understanding the enrichment of APAP promoted by hydrogen bonds on the surface of simulated cell membrane and the design of APAP sensors.
- Acetaminophen,
- Hydrogen bond,
- Enrichment,
- Self-assembled monolayer,
- Scanning electrochemical microscopy
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