Citation: WANG Chen, LI Kai, MIN Qian-Hao. Advances in Portable Microdevice Coupled Mass Spectrometry for Biological Detection[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(11): 1685-1698. doi: 10.19756/j.issn.0253-3820.221005 shu

Advances in Portable Microdevice Coupled Mass Spectrometry for Biological Detection

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: MIN Qian-Hao, minqianhao@nju.edu.cn
Received Date: 13 January 2022
Revised Date: 13 March 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21974062, 92053102).

Portable microdevice coupled mass spectrometry (MS) has shown great capability of rapid sampling and high-throughput assay of biological samples by simplifying sample pretreatment while maintaining the sensitivity and reliability of MS detection. Particularly, paper substrates, microextraction devices and microchips allow the integration of fast sampling, desalting and extraction. Mass spectrometric methods coupled with above portable microdevices show great sensitivity and selectivity in biological detections, thus facilitating their applications in therapeutic drug monitoring, endogenous substrate detection, protein and peptide detection, and bacterial identification. This review summarizes the main principles and research progress of portable microdevice coupled mass spectrometry (e.g. paper spray-MS, microextraction-MS, and microfluidic chip-MS), and also prospects their future developments and potential applications.
- Portable microdevice,
- Mass spectrometry,
- Paper spray,
- Microextraction,
- Microchip,
- Review
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