Citation: YE Jia-Yue, ZENG Wei-Biao, WEI Yi-Ping. Application of Direct Injection Mass Spectrometry in Clinical Diagnosis of Thoracic Tumors[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 484-491. doi: 10.19756/j.issn.0253-3820.211216 shu

Application of Direct Injection Mass Spectrometry in Clinical Diagnosis of Thoracic Tumors

Department of Thoracic Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

Corresponding author: WEI Yi-Ping, weiyip2000@hotmail.com
Received Date: 17 March 2021
Revised Date: 4 October 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 81860379, 82160410).

Mass spectrometry (MS) analysis has become one of the core technologies for clinical disease research. Traditional mass spectrometry techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) often require multi-step pre-processing of different clinical samples, which can not meet the practical requirements of large samples and high throughput analysis in clinical settings, while these needs are driving the development of new technologies for mass spectrometry from laboratory to clinical applications. The lack of ideal preoperative diagnostic protocols for chest malignancies such as lung cancer and esophageal cancer, the long waiting time for intraoperative pathology to assess the nature of the cut edge, and the lack of ideal models to assess the risk of recurrence in the postoperative period are among the main reasons for ″under-treatment″ and ″over-treatment″ in clinical practice. This is one of the main reasons for ″under-treatment″ and ″over-treatment″ in clinical practice. Direct injection mass spectrometry has high specificity and sensitivity, which effectively improves the accuracy of sample nature determination and decreases the analysis time of samples in clinical analysis, providing important guidance for clinical diagnosis and chest tumor research. This review introduced the progress of the application of direct injection mass spectrometry in the perioperative diagnosis of thoracic tumors, and briefly described the prospects of the application of direct injection mass spectrometry combined with histological methods to explore thoracic tumor biomarkers for the prevention of postoperative recurrence.
- Mass spectrometry,
- Direct injection mass spectrometry,
- Thoracic tumor,
- Clinical diagnosis,
- Review
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