Citation: CHEN Huan, HAN Xin-Tao, WEI Jia, LIU Jia-Nan, WANG Guo-Qing, LIU Wan-Jian, TIAN Yong-Shuai, MENG Xian-Ying, WANG Zhen-Xin. Recent Progress of Detection of Circulating Tumor DNA[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(6): 893-906. doi: 10.19756/j.issn.0253-3820.211106 shu

Recent Progress of Detection of Circulating Tumor DNA

1.
Qingdao HIGHTOP Biotech Co., Ltd., Qingdao 266000, China;
2.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
3.
Department of Thyroid Surgery, the First Hospital of Jilin University, Changchun 130021, China

Corresponding author: TIAN Yong-Shuai, MENG Xian-Ying, WANG Zhen-Xin,
Received Date: 4 February 2021
Revised Date: 31 March 2021

Fund Project: Supported by the Natural Science Foundation of Jilin Province (No.20200201357JC) and the Shandong Taishan Industry Leading Talent Project, China (No.2019TSCYCX-24).

Circulating tumor DNA (ctDNA) is a kind of cell-free DNA (cfDNA) derived from tumor, which may carry the same carcinogenic mutations and genetic alterations as those of a primary tumor. Because ctDNA is expected to be a molecular biomarker for non-invasive monitoring of cancer, the development of ctDNA analysis methods can efficiently promote the development of liquid biopsy technology for cancer diagnosis, prognosis evaluation, efficacy monitoring and genetic/epigenetic abnormalities. In the past decades, traditional DNA detection techniques such as polymerase chain reaction (PCR) and next generation sequencing (NGS) were applied to clinical detection of ctDNA. Recently, biosensors have been gradually employed to analyze ctDNA in blood samples in cancer patients, which bring new tools for detection of ctDNA. In this review, the ctDNA analysis methods, especially the new progress of ctDNA biosensors in recent five years, have been summarized. The currently technical challenges of these methods in clinical practice have also been briefly discussed, which may provide useful information for developing new liquid biopsy methods of cancer.
- Circulating tumor DNA,
- Molecular biomarkers,
- Liquid biopsy,
- Biosensor,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142