Citation: ZHAN Jia-Yin, LIU Ran, ZHANG Jing-Jing. Progress of Stimuli-responsive Nanomaterials in Tumor Analysis[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1133-1141. doi: 10.19756/j.issn.0253-3820.211086 shu

Progress of Stimuli-responsive Nanomaterials in Tumor Analysis

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China

Corresponding author: ZHANG Jing-Jing, jing15209791@nju.edu.cn
Received Date: 29 January 2021
Revised Date: 12 April 2021

Fund Project: Supported by the National Natural Science Foundation of China (No. 22004063), the Natural Science Foundation of Jiangsu Province (No. 20200303) and the Innovation Fund of Nanjing University (No. 020514913414).

Under the trigger of endogenous stimuli (such as pH, overexpressed enzymes, redox, etc.) or exogenous stimuli (such as light, temperature, magnetic fields, etc.), stimuli-responsive nanomaterials can change their structures and properties in tumor tissues, so as to achieve precise drug delivery and imaging. Due to the differences in structure, composition and function, these stimuli-responsive nanomaterials have exhibited diverse applications, such as photothermal therapy, chemotherapy or imaging by triggered drug delivery. To explore the potential applications of stimuli-responsive nanomaterials, this review focuses on exogenous light-responsive and/or endogenous enzyme-responsive nanomaterials and summarizes the research progress in the areas of tumor-related therapy and bioimaging in the past few years.
- Light-responsive,
- Enzyme-responsive,
- Nanomaterials,
- Oncotherapy,
- Bioimaging,
- Review
1. [1]
  HANAHAN D, WEINBERG R A. Cell, 2011, 144(5): 646-674.
2. [2]
  CHINEN A B, GUAN C M, FERRER J R, BARNABY S N, MERKEL T J, MIRKIN C A. Chem. Rev., 2015, 115(19): 10530-10574.
3. [3]
  SHI J J, KANTOFF P W, WOOSTER R, FAROKHZAD O C. Nat. Rev. Cancer, 2017, 17(1): 20-37.
4. [4]
  DONG P, RAKESH K P, MANUKUMAR H M, MOHAMMED Y H E, KARTHIK C S, SUMATHI S, MALLU P, QIN H L. Bioorg. Chem., 2019, 85: 325-336.
5. [5]
  KASHKOOLI F M, SOLTANI M, SOURI M. J. Controlled Release, 2020, 327: 316-349.
6. [6]
  THAKKAR S, SHARMA D, KALIA K, TEKADE R K. Acta Biomater., 2020, 101: 43-68.
7. [7]
  PHAM S H, CHOI Y, CHOI J. Pharmaceutics, 2020, 12(7): 630.
8. [8]
  RACCA L, CAUDA V. Nano-Micro Lett., 2020, 13(1): 11.
9. [9]
  ZHANG M, GUO X L, WANG M F, LIU K H. J. Controlled Release, 2020, 323: 203-224.
10. [10]
  ALEJO T, USON L, ARRUEBO M. J. Controlled Release, 2019, 314: 162-176.
11. [11]
  RAZA A, RASHEED T, NABEEL F, HAYAT U, BILAL M, IQBAL H M N. Molecules, 2019, 24(6): 1117.
12. [12]
  LUO Z M, JIN K, PANG Q, SHEN S, YAN Z Q, JIANG T, ZHU X Y, YU L, PANG Z Q, JIANG X G. ACS Appl. Mater. Interfaces, 2017, 9(37): 31612-31625.
13. [13]
  ESPINOSA A, DI CORATO R, KOLOSNJAJ-TABI J, FLAUD P, PELLEGRINO T, WILHELM C. ACS Nano, 2016, 10(2): 2436-2446.
14. [14]
  SANEJA A, KUMAR R, ARORA D, KUMAR S, PANDA A K, JAGLAN S. Drug Discov. Today, 2018, 23(5): 1115-1125.
15. [15]
  KATO Y, OZAWA S, MIYAMOTO C, MAEHATA Y, SUZUKI A, MAEDA T, BABA Y. Cancer Cell Int., 2013, 13(1): 1-8.
16. [16]
  LI Y, GAO G H, LEE D S. J. Polym. Sci., Part A: Polym. Chem., 2013, 51(19): 4175-4182.
17. [17]
  THOMAS R G, SURENDRAN S P, JEONG Y Y. Front. Mol. Biosci., 2020, 7: 1516-1526.
18. [18]
  LI M, ZHAO G, SU W K, SHUAI Q. Front. Chem., 2020, 8: 647.
19. [19]
  MI P. Theranostics, 2020, 10(10): 4557-4588.
20. [20]
  MOHAPATRA A, UTHAMAN S, PARK I K. Front. Mol. Biosci., 2021, 7: 597634.
21. [21]
  DYKMAN L, KHLEBTSOV N. Chem. Soc. Rev., 2012, 41(6): 2256-2282.
22. [22]
  CASTILLO R R, LOZANO D, GONZALEZ B, MANZANO M, IZQUIERDO-BARBA I, VALLET-REGI M. Expert Opin. Drug Deliv., 2019, 16(4): 415-439.
23. [23]
  DONG H, DU S R, ZHENG X Y, LYU G M, SUN L D, LI L D, ZHANG P Z, ZHANG C, YAN C H. Chem. Rev., 2015, 115(19): 10725-10815.
24. [24]
  LI L, XING H, ZHANG J, LU Y. Acc. Chem. Res., 2019, 52(9): 2415-2426.
25. [25]
  MAL N K, FUJIWARA M, TANAKA Y. Nature, 2003, 421(6921): 350-353.
26. [26]
  WANG X R, HU J M, LIU G H, TIAN J, WANG H J, GONG M, LIU S Y. J. Am. Chem. Soc., 2015, 137(48): 15262-15275.
27. [27]
  LIU Y, HE M, NIU M M, ZHAO Y Q, ZHU Y Z, LI Z H, FENG N P. Int. J. Nanomed., 2015, 10: 3081-3095.
28. [28]
  MARTINEZ-CARMONA M, LOZANO D, BAEZA A, COLILLA M, VALLET-REGI M. Nanoscale, 2017, 9(41): 15967-15973.
29. [29]
  YANG G B, LIU J J, WU Y F, FENG L Z, LIU Z. Coord. Chem. Rev., 2016, 320: 100-117.
30. [30]
  YUAN A, WU J, TANG X, ZHAO L, XU F, HU Y. J. Pharm. Sci., 2013, 102(1): 6-28.
31. [31]
  LI X N, SCHUMANN C, ALBARQI H A, LEE C J, ALANI A W G, BRACHA S, MILOVANCEV M, TARATULA O, TARATULA O. Theranostics, 2018, 8(3): 767-784.
32. [32]
  ZHAO J, CHU H, ZHAO Y, LU Y, LI L. J. Am. Chem. Soc., 2019, 141(17): 7056-7062.
33. [33]
  CHU H, ZHAO J, MI Y, ZHAO Y, LI L. Angew. Chem., Int. Ed., 2019, 58(42): 14877-14881.
34. [34]
  LI C Y, ZHENG B, KANG Y F, TANG H W, PANG D W. ACS Sens., 2020, 5(1): 199-207.
35. [35]
  HUANG L, LI Z J, ZHAO Y, ZHANG Y W, WU S, ZHAO J Z, HAN G. J. Am. Chem. Soc., 2016, 138(44): 14586-14591.
36. [36]
  VANKAYALA R, KUO C L, NUTHALAPATI K, CHIANG C S, HWANG K C. Adv. Funct. Mater., 2015, 25(37): 5934-5945.
37. [37]
  GOODMAN A M, NEUMANN O, NORREGAARD K, HENDERSON L, CHOI M R, CLARE S E, HALAS N J. Proc. Natl. Acad. Sci. U. S. A., 2017, 114(47): 12419-12424.
38. [38]
  DAI Y L, BI H T, DENG X R, LI C X, HE F, MA P A, YANG P P, LIN J. J. Mat. Chem. B, 2017, 5(11): 2086-2095.
39. [39]
  LIU D, YANG F, XIONG F, GU N. Theranostics, 2016, 6(9): 1306-1323.
40. [40]
  JO Y, CHOI N, KIM K, KOO H J, CHOI J, KIM H N. Theranostics, 2018, 8(19): 5259-5275.
41. [41]
  EGEBLAD M, WERB Z. Nat. Rev. Cancer, 2002, 2(3): 161-174.
42. [42]
  LI X, KIM J, YOON J, CHEN X Y. Adv. Mater., 2017, 29(23): 1606857
43. [43]
  CALLMANN C E, BARBACK C V, THOMPSON M P, HALL D J, MATTREY R F, GIANNESCHI N C. Adv. Mater., 2015, 27(31): 4611-4615.
44. [44]
  HU X, YANG P, HE J, LIANG R, NIU D, WANG H, LI Y. J. Mater. Chem. B, 2017, 5(30): 5931-5936.
45. [45]
  LIU Y, DING X, LI J, LUO Z, HU Y, LIU J, DAI L, ZHOU J, HOU C, CAI K. Nanotechnology, 2015, 26(14): 145102
46. [46]
  HAN H J, VALDEPEREZ D, JIN Q, YANG B, LI Z H, WU Y L, PELAZ B, PARAK W J, JI J. ACS Nano, 2017, 11(2): 1281-1291.
47. [47]
  LI H, WANG P, DENG Y X, ZENG M Y, TANG Y, ZHU W H, CHENG Y S. Biomaterials, 2017, 139: 30-38.
48. [48]
  WHITE B D, DUAN C, TOWNLEY H E. Biomolecules, 2019, 9(5): 202.
49. [49]
  HUANG Y, SONG C, LI H, ZHANG R, JIANG R, LIU X, ZHANG G, FAN Q, WANG L, HUANG W. ACS Appl. Mater. Interfaces, 2015, 7(38): 21529-21537.
50. [50]
  SHI H, GAO T, SHI L, CHEN T S, XIANG Y, LI Y Y, LI G X. Sci. Rep., 2018, 8: 16341.
51. [51]
  YUE X, QIAO Y, GU D, WU Z, ZHAO W, LI X, YIN Y, ZHAO W, KONG D, XI R, MENG M. Sens. Actuators, B, 2020, 312: 127943.
52. [52]
  ZHENG F F, WANG C, MENG T T, ZHANG Y Q, ZHANG P H, SHEN Q, ZHANG Y C, ZHANG J F, LI J X, MIN Q H, CHEN J N, ZHU J J. ACS Nano, 2019, 13(11): 12577-12590.
53. [53]
  CHEN C Y, KIM T H, WU W C, HUANG C M, WEI H, MOUNT C W, TIAN Y, JANG S H, PUN S H, JEN A K Y. Biomaterials, 2013, 34(18): 4501-4509.
54. [54]
  DUTTA S, SAMANTA P, DHARA D. Int. J. Biol. Macromol., 2016, 87: 92-100.
55. [55]
  AN X, ZHU A, LUO H, KE H, CHEN H, ZHAO Y. ACS Nano, 2016, 10(6): 5947-5958.
56. [56]
  YANG K, LIU Y, WANG Y, REN Q, GUO H, MATSON J B, CHEN X, NIE Z. Biomaterials, 2019, 223: 119460.
57. [57]
  GAO S, ZHANG L W, WANG G H, YANG K, CHEN M L, TIAN R, MA Q J, ZHU L. Biomaterials, 2016, 79: 36-45.
1. [1]
  Jian Li , Yu Zhang , Rongrong Yan , Kaiyuan Sun , Xiaoqing Liu , Zishang Liang , Yinan Jiao , Hui Bu , Xin Chen , Jinjin Zhao , Jianlin Shi . 高效靶向示踪钙钛矿纳米系统光电增效抗肿瘤. Acta Physico-Chimica Sinica, 2025, 41(5): 100042-. doi: 10.1016/j.actphy.2024.100042
2. [2]
  Lina Feng , Guoyu Jiang , Xiaoxia Jian , Jianguo Wang . Application of Organic Radical Materials in Biomedicine. University Chemistry, 2025, 40(4): 253-260. doi: 10.12461/PKU.DXHX202405171
3. [3]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
4. [4]
  Zunyuan Xie , Lijin Yang , Zixiao Wan , Xiaoyu Liu , Yushan He . Exploration of the Preparation and Characterization of Nano Barium Titanate and Its Application in Inorganic Chemistry Laboratory Teaching. University Chemistry, 2024, 39(4): 62-69. doi: 10.3866/PKU.DXHX202310137
5. [5]
  Juan Yuan , Bin Zhang , Jinping Wu , Mengfan Wang . Design of a Comprehensive Experiment on Preparation and Characterization of Cu₂(Salen)₂ Nanomaterials with Two Distinct Morphologies. University Chemistry, 2024, 39(10): 420-425. doi: 10.3866/PKU.DXHX202402014
6. [6]
  Simin Fang , Wei Huang , Guanghua Yu , Cong Wei , Mingli Gao , Guangshui Li , Hongjun Tian , Wan Li . Integrating Science and Education in a Comprehensive Chemistry Design Experiment: The Preparation of Copper(I) Oxide Nanoparticles and Its Application in Dye Water Remediation. University Chemistry, 2024, 39(8): 282-289. doi: 10.3866/PKU.DXHX202401023
7. [7]
  Bing WEI , Jianfan ZHANG , Zhe CHEN . Research progress in fine tuning of bimetallic nanocatalysts for electrocatalytic carbon dioxide reduction. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 425-439. doi: 10.11862/CJIC.20240201
8. [8]
  Wenjun Zheng . Application in Inorganic Synthesis of Ionic Liquids. University Chemistry, 2024, 39(8): 163-168. doi: 10.3866/PKU.DXHX202401020
9. [9]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
10. [10]
  Baohua LÜ , Yuzhen LI . Anisotropic photoresponse of two-dimensional layered α-In₂Se₃(2H) ferroelectric materials. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1911-1918. doi: 10.11862/CJIC.20240105
11. [11]
  Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
12. [12]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
13. [13]
  Xinzhe HUANG , Lihui XU , Yue YANG , Liming WANG , Zhangyong LIU , Zhongjian WANG . Preparation and visible light responsive photocatalytic properties of BiSbO₄/BiOBr. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 284-292. doi: 10.11862/CJIC.20240212
14. [14]
  Xiyuan Su , Zhenlin Hu , Ye Fan , Xianyuan Liu , Xianyong Lu . Change as You Want: Multi-Responsive Superhydrophobic Intelligent Actuation Material. University Chemistry, 2024, 39(5): 228-237. doi: 10.3866/PKU.DXHX202311059
15. [15]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
16. [16]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
17. [17]
  Xiufang Wang , Donglin Zhao , Kehua Zhang , Xiaojie Song . “Preparation of Carbon Nanotube/SnS₂ Photoanode Materials”: A Comprehensive University Chemistry Experiment. University Chemistry, 2024, 39(4): 157-162. doi: 10.3866/PKU.DXHX202308025
18. [18]
  Li'na ZHONG , Jingling CHEN , Qinghua ZHAO . Synthesis of multi-responsive carbon quantum dots from green carbon sources for detection of iron ions and L-ascorbic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 709-718. doi: 10.11862/CJIC.20240280
19. [19]
  Meiqing Yang , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-. doi: 10.3866/PKU.WHXB202310046
20. [20]
  . . Chinese Journal of Inorganic Chemistry, 2024, 40(12): 0-0.

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(659)
HTML views(50)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142