Citation: DUAN Pan-Hui, MENG Ke, ZHANG Yi-Wen, GAO Hui, MA Kang. Identification of Organic Impurities in Ractopamine Reference Material[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(4): 554-562. doi: 10.19756/j.issn.0253-3820.211031 shu

Identification of Organic Impurities in Ractopamine Reference Material

DUAN Pan-Hui ^1,2 ,
MENG Ke ³ ,
ZHANG Yi-Wen ⁴ ,
GAO Hui ⁵ ,
MA Kang ^1,,

1.
National Institute of Metrology of China, Beijing 100029, China;
2.
College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China;
3.
Jiangsu Institute of Metrology, Nanjing 210007, China;
4.
Beijing Institute of Metrology, Beijing 100029, China;
5.
Shimadzu(China) Limited Co, Beijing 100020, China

Corresponding author: MA Kang, makang@nim.ac.cn
Received Date: 14 January 2021
Revised Date: 2 March 2021

Fund Project: Supported by the National Key Research and Development Program of China(Nos.2018YFF0212800, 2018YFF0212801) and the Basic Scientific Research Expenses(No.21-AKY-1960).

Ractopamine (RAC) is a synthetic β-adrenergic receptor agonist and one of the lean meat powder substances. The purity standard substance is the source of the traceability of the value. In this work, the organic impurities in RAC were analyzed by high performance liquid chromatography quadrupole-time of flight mass spectrometry (HPLC-Q-TOF/MS), including 4 main organic impurities A (m/z 286.1802), B (m/z 316.1907), C (m/z 438.2275) and D (m/z 372.2533). The range of impurity's fragment ion peak mass deviation (m/z) was (-0.6-0.6) mDa and the relative mass deviation was from -3.7×10^-6 to 2.1×10^-6. Using mass spectrometry data, the fragmentation pathway of ractopamine and the fragment ions of organic impurities was established. It was inferred that impurity A was a byproduct of the dehydration and hydrogenation of ractopamine, and B, C, D and ractopamine had the same molecular skeleton structure. In addition, high-performance liquid chromatography ion trap-time of flight mass spectrometry (HPLC-IT-TOF/MS) was used to compare and verify the mass spectra fragments of organic impurities. The results showed that the two different types of mass spectrometry were consistnet. This study provided a new way of verifying results for the accurate qualitative determination of organic impurities.
- Ractopamine,
- Quadrupole-time of flight mass spectrometry,
- Ion trap-time of flight mass spectrometry,
- Organic impurities
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