Citation: LIU Meng-Yuan, WANG Shu-Qi, ZHENG Hui, YANG Xian-Qing, ZHANG Ting. Research Progress of Flexible Wearable Sweat Sensors Based on Microchannel Design[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(11): 1627-1638. doi: 10.19756/j.issn.0253-3820.210902 shu

Research Progress of Flexible Wearable Sweat Sensors Based on Microchannel Design

1.
Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China;
2.
Nanjing University of Science and Technology, Nanjing 210094, China;
3.
Gusu Laboratory of Materials, Suzhou 215123, China

Corresponding author: WANG Shu-Qi, ZHANG Ting,
Received Date: 23 December 2021
Revised Date: 16 February 2022

Fund Project: Supported by the National Key Research and Development Program of China (No.2018YFB1304700) and the National Natural Science Foundation of China (Nos.62071463, 61801473, 62125112).

In recent years, with the development of flexible electronics and microfluids, various flexible wearable sweat sensors based on microchannel have been developed, and exhibit excellent development prospect. In this paper, the advantages of flexible wearable sensors based on microchannel design for sweat detection were introduced, and the research progress of the principles of structural design, detection methods and microchannel sweat detection sensors was summarized. The deficiencies and limitations of microchannel sweat sensors were analyzed.The review pointed out that the sweat sensors based on microfluidic channel design should be developed in the direction of low cost and mass production, and it was important to further study the relationship between sweat parameters and human physiological health.
- Wearable devices,
- Sweat sensor,
- Sweat detecting,
- Sweat rate,
- Review
1. [1]
  IQBAL S M A, MAHGOUB I, DU E, LEAVITT M A, ASGHAR W. npj Flexible Electron., 2021, 5(1):9.
2. [2]
  QIAO L, BENZIGAR M R, SUBRAMONY J A, LOVELL N H, LIU G J A A M, INTERFACE S. ACS Appl. Mater. Interfaces, 2020, 12(30):34337-34361.
3. [3]
  RAY T R, CHOI J, BANDODKAR A J, KRISHNAN S, GUTRUF P, TIAN L M, GHAFFARI R, ROGERS J A. Chem. Rev., 2019, 119(8):5461-5533.
4. [4]
  HEIKENFELD J, JAJACK A, ROGERS J, GUTRUF P, TIAN L, PAN T, LI R, KHINE M, KIM J, WANG J, KIM J. Lab Chip, 2018, 18(2):217-248.
5. [5]
  KIM J, CAMPBELL A S, DE AVILA B E F, WANG J. Nat. Biotechnol., 2019, 37(4):389-406.
6. [6]
  MA C, MA M G, SI C L, JI X X, WAN P B. Adv. Funct. Mater., 2021, 31(22):2009524.
7. [7]
  LIU Y, PHARR M, SALVATORE G A. ACS Nano, 2017, 11(10):9614-9635.
8. [8]
  BANDODKAR A J, WANG J. Trends Biotechnol., 2014, 32(7):363-371.
9. [9]
  YANG Y R, GAO W. Chem. Soc. Rev., 2019, 48(6):1465-1491.
10. [10]
  LIN Y, BARIYA M, JAVEY A. Adv. Funct. Mater., 2020, 31(39):2008087.
11. [11]
  GHAFFARI R, ROGERS J A, RAY T R. Sens. Actuators, B, 2021, 332:129447.
12. [12]
  YU H, SUN J J N, ENGINEERING P. Nanotechnol. Precis. Eng., 2020, 3(3):126-140.
13. [13]
  WANG Z, SHIN J, PARK J H, LEE H, KIM D H, LIU H. Adv. Funct. Mater., 2020, 31(12):2008130.
14. [14]
  MOHAN A M V, RAJENDRAN V, MISHRA R K, JAYARAMAN M. TrAC, Trends Anal. Chem., 2020, 131:116024.
15. [15]
  ZHONG B W, JIANG K, WANG L L, SHEN G Z. Adv. Sci., 2021, 9(1):2103257.
16. [16]
  RAY T R, IVANOVIC M, CURTIS P M, FRANKLIN D, GUVENTURK K, JEANG W J, CHAFETZ J, GAERTNER H, YOUNG G, REBOLLO S, MODEL J B, LEE S P, CIRALDO J, REEDER J T, HOURLIER-FARGETTE A, BANDODKAR A J, CHOI J, ARANYOSI A J, GHAFFARI R, MCCOLLEY S A, HAYMOND S, ROGERS J A. Sci. Transl. Med., 2021, 13(587):eabd8109.
17. [17]
  ZHAI Q, YAP L W, WANG R, GONG S, GUO Z, LIU Y, LYU Q, WANG J, SIMON G P, CHENG W. Anal. Chem., 2020, 92(6):4647-4655.
18. [18]
  GAO W, EMAMINEJAD S, NYEIN H Y Y, CHALLA S, CHEN K V, PECK A, FAHAD H M, OTA H, SHIRAKI H, KIRIYA D, LIEN D H, BROOKS G A, DAVIS R W, JAVEY A. Nature, 2016, 529(7587):509-514.
19. [19]
  HAMMOND K B, TURCIOS N L, GIBSON L E. J. Pediatr., 1994, 124(2):255-260.
20. [20]
  POLETTI F, ZANFROGNINI B, FAVARETTO L, QUINTANO V, SUN J, TREOSSI E, MELUCCI M, PALERMO V, ZANARDI C. Sens. Actuators, B, 2021, 344:130253.
21. [21]
  LEE H B, MEESEEPONG M, TRAN QUANG T, KIM B Y, LEE N E. Biosens. Bioelectron., 2020, 156:112133.
22. [22]
  TANG W, YIN L, SEMPIONATTO J R, MOON J M, TEYMOURIAN H, WANG J. Adv. Mater., 2021, 33(18):2008465.
23. [23]
  CHOI J, GHAFFARI R, BAKER L B, ROGERS J A. Sci. Adv., 2018, 4(2):eaar3921.
24. [24]
  NYEIN H Y Y, BARIYA M, TRAN B, AHN C H, BROWN B J, JI W, DAVIS N, JAVEY A. Nat. Commun., 2021, 12(1):1823.
25. [25]
  ZHAO F J, BONMARIN M, CHEN Z C, LARSON M, FAY D, RUNNOE D, HEIKENFELD J. Lab Chip, 2020, 20(1):168-174.
26. [26]
  KWON K, KIM J U, DENG Y, KRISHNAN S R, CHOI J, JANG H, LEE K, SU C J, YOO I, WU Y, LIPSCHULTZ L, KIM J H, CHUNG T S, WU D, PARK Y, KIM T I, GHAFFARI R, LEE S, HUANG Y, ROGERS J A. Nat. Electron., 2021, 4(4):302-314.
27. [27]
  BAKER L B, WOLFE A S. Eur. J. Appl. Physiol., 2020, 120(4):719-752.
28. [28]
  BARNES K A, ANDERSON M L, STOFAN J R, DALRYMPLE K J, REIMEL A J, ROBERTS T J, RANDELL R K, UNGARO C T, BAKER L B. J. Sports Sci., 2019, 37(20):2356-2366.
29. [29]
  ZHAO Z, LI Q, DONG Y, GONG J, LI Z, ZHANG J. Sens. Actuators, B, 2022, 353:131154.
30. [30]
  SON J, BAE G Y, LEE S, LEE G, KIM S W, KIM D, CHUNG S, CHO K. Adv. Mater., 2021, 33(40):2102740.
31. [31]
  CHEN Y C, SHAN S S, LIAO Y T, LIAO Y C. Lab Chip, 2021, 21(13):2524-2533.
32. [32]
  ZHANG Y X, CHEN Y, HUANG J L, LIU Y C Y, PENG J F, CHEN S D, SONG K, OUYANG X P, CHENG H Y, WANG X F. Lab Chip, 2020, 20(15):2635-2645.
33. [33]
  WANG S, WU Y, GU Y, LI T, LUO H, LI L H, BAI Y, LI L, LIU L, CAO Y, DING H, ZHANG T. Anal. Chem., 2017, 89(19):10224-10231.
34. [34]
  SCHAZMANN B, MORRIS D, SLATER C, BEIRNE S, FAY C, REUVENY R, MOYNA N, DIAMOND D. Anal. Methods, 2010, 2(4):342-348.
35. [35]
  PIROVANO P, DORRIAN M, SHINDE A, DONOHOE A, BRADY A J, MOYNA N M, WALLACE G, DIAMOND D, MCCAUL M. Talanta, 2020, 219:121145.
36. [36]
  WANG S, BAI Y, YANG X, LIU L, LI L, LU Q, LI T, ZHANG T. Talanta, 2020, 214:120869.
37. [37]
  EMAMINEJAD S, GAO W, WU E, DAVIES Z A, NYEIN H Y Y, CHALLA S, RYAN S P, FAHAD H M, CHEN K, SHAHPAR Z, TALEBI S, MILLA C, JAVEY A, DAVIS R W. Proc. Natl. Acad. Sci. U.S.A., 2017, 114(18):4625-4630.
38. [38]
  PATTERSON M J, GALLOWAY S D R, NIMMO M A. Exp. Physiol., 2000, 85(6):869-875.
39. [39]
  NYEIN H Y Y, GAO W, SHAHPAR Z, EMAMINEJAD S, CHALLA S, CHEN K, FAHAD H M, TAI L C, OTA H, DAVIS R W, JAVEY A. ACS Nano, 2016, 10(7):7216-7224.
40. [40]
  HE X, XU T, GU Z, GAO W, XU L P, PAN T, ZHANG X. Anal. Chem., 2019, 91(7):4296-4300.
41. [41]
  GUINOVART T, BANDODKAR A J, WINDMILLER J R, ANDRADE F J, WANG J. Analyst, 2013, 138(22):7031-7038.
42. [42]
  BANDODKAR A J, CHOI J, LEE S P, JEANG W J, AGYARE P, GUTRUF P, WANG S Q, SPONENBURG R A, REEDER J T, SCHON S, RAY T R, CHEN S L, MEHTA S, RUIZ S, ROGERS J A. Adv. Mater., 2019, 31(32):1902109.
43. [43]
  GAO W, NYEIN H Y Y, SHAHPAR Z, FAHAD H M, CHEN K, EMAMINEJAD S, GAO Y J, TAI L C, OTA H, WU E, BULLOCK J, ZENG Y P, LIEN D H, JAVEY A. ACS Sens., 2016, 1(7):866-874.
44. [44]
  ANASTASOVA S, CREWTHER B, BEMBNOWICZ P, CURTO V, IP H M D, ROSA B, YANG G Z. Biosens. Bioelectron., 2017, 93:139-145.
45. [45]
  LI M, WANG L, LIU R, LI J, ZHANG Q, SHI G, LI Y, HOU C, WANG H. Biosens. Bioelectron., 2021, 174:112828.
46. [46]
  ABELLAN-LLOBREGAT A, JEERAPAN I, BANDODKAR A, VIDAL L, CANALS A, WANG J, MORALLON E. Biosens. Bioelectron., 2017, 91:885-891.
47. [47]
  KIM J, JEERAPAN I, IMANI S, CHO T N, BANDODKAR A, CINTI S, MERCIER P P, WANG J. ACS Sens., 2016, 1(8):1011-1019.
48. [48]
  KINNAMON D, GHANTA R, LIN K C, MUTHUKUMAR S, PRASAD S. Sci. Rep., 2017, 7:13312.
49. [49]
  WINDMILLER J R, BANDODKAR A J, VALDES-RAMIREZ G, PARKHOMOVSKY S, MARTINEZ A G, WANG J. Chem. Commun., 2012, 48(54):6794-6796.
50. [50]
  YANG Y, SONG Y, BO X, MIN J, PAK O S, ZHU L, WANG M, TU J, KOGAN A, ZHANG H, HSIAI T K, LI Z, GAO W. Nat. Biotechnol., 2020, 38(2):217-224.
51. [51]
  HOURLIER-FARGETTE A, SCHON S, XUE Y, AVILA R, LI W, GAO Y, LIU C, KIM S B, RAJ M S, FIELDS K B, PARSONS B V, LEE K, LEE J Y, CHUNG H U, LEE S P, JOHNSON M, BANDODKAR A J, GUTRUF P, MODEL J B, ARANYOSI A J, CHOI J, RAY T R, GHAFFARI R, HUANG Y, ROGERS J A. Lab Chip, 2020, 20(23):4391-4403.
52. [52]
  LEGNER C, KALWA U, PATEL V, CHESMORE A, PANDEY S. Sens. Actuators, A, 2019, 296:200-221.
53. [53]
  CHOI J, CHEN S, DENG Y, XUE Y, REEDER J T, FRANKLIN D, OH Y S, MODEL J B, ARANYOSI A J, LEE S P, GHAFFARI R, HUANG Y, ROGERS J A. Adv. Healthcare Mater., 2021, 10(4):2000722.
54. [54]
  CHOI D H, GONZALES M, KITCHEN G B, PHAN D T, SEARSON P C. ACS Sens., 2020, 5(12):3821-3826.
55. [55]
  KIM S B, LEE K, RAJ M S, LEE B, REEDER J T, KOO J, HOURLIER-FARGETTE A, BANDODKAR A J, WON S M, SEKINE Y, CHOI J, ZHANG Y, YOON J, KIM B H, YUN Y, LEE S, SHIN J, KIM J, GHAFFARI R, ROGERS J A. Small, 2018, 14(45):1802876.
56. [56]
  CHUNG M, FORTUNATO G, RADACSI N. J. R. Soc., Interface, 2019, 16(159):20190217.
57. [57]
  ZAMARAYEVA A M, YAMAMOTO N A D, TOOR A, PAYNE M E, WOODS C, PISTER V I, KHAN Y, EVANS J W, ARIAS A C. APL Mater., 2020, 8(10):100905.
58. [58]
  HUANG X, YEO W H, LIU Y, ROGERS J A. Biointerphases, 2012, 7(1-4):52.
59. [59]
  TANG L, LEE N Y. Lab Chip, 2010, 10(10):1274-1280.
60. [60]
  WU W, WU J, KIM J H, LEE N Y. Lab Chip, 2015, 15(13):2819-2825.
61. [61]
  ARAN K, SASSO L A, KAMDAR N, ZAHN J D. Lab Chip, 2010, 10(5):548-552.
62. [62]
  NGUYEN T, JUNG S H, LEE M S, PARK T E, AHN S K, KANG J H. Lab Chip, 2019, 19(21):3706-3713.
63. [63]
  YUAN Z, HOU L, BARIYA M, NYEIN H Y Y, TAI L C, JI W B, LIABC L, JAVEY A. Lab Chip, 2019, 19(19):3179-3189.
64. [64]
  WEI L, FANG G, KUANG Z, CHENG L, WU H, GUO D, LIU A. Sens. Actuators, B, 2021, 353:131085.
65. [65]
  ALVAREZ-BRAÑA Y, ETXEBARRIA-ELEZGARAI J, RUIZ DE LARRINAGA-VICENTE L, BENITO-LOPEZ F, BASABE-DESMONTS L. Sens. Actuators, B, 2021, 342:129991.
66. [66]
  REEDER J T, CHOI J, XUE Y G, GUTRUF P, HANSON J, LIU M, RAY T, BANDODKAR A J, AVILA R, XIA W, KRISHNAN S, XU S, BARNES K, PAHNKE M, GHAFFARI R, HUANG Y, ROGERS J A. Sci. Adv., 2019, 5(1):eaau6356.
67. [67]
  REEDER J T, XUE Y, FRANKLIN D, DENG Y, CHOI J, PRADO O, KIM R, LIU C, HANSON J, CIRALDO J, BANDODKAR A J, KRISHNAN S, JOHNSON A, PATNAUDE E, AVILA R, HUANG Y, ROGERS J A. Nat. Commun., 2019, 10:5513.
68. [68]
  BAKER L B, MODEL J B, BARNES K A, ANDERSON M L, LEE S P, LEE K A, BROWN S D, REIMEL A J, ROBERTS T J, NUCCIO R P, BONSIGNORE J L, UNGARO C T, CARTER J M, LI W, SEIB M S, REEDER J T, ARANYOSI A J, ROGERS J A, GHAFFARI R. Sci. Adv., 2020, 6(50):eabe3929.
69. [69]
  NYEIN H Y Y, BARIYA M, KIVIMÄKI L, UUSITALO S, LIAW T S, JANSSON E, AHN C H, HANGASKY J A, ZHAO J, LIN Y, HAPPONEN T, CHAO M, LIEDERT C, ZHAO Y, TAI L C, HILTUNEN J, JAVEY A. Sci. Adv., 2019, 5(8):eaaw9906.
70. [70]
  JIA T, WANG Y, DOU Y, LI Y, DE ANDRADE M J, WANG R, FANG S, LI J, YU Z, QIAO R, LIU Z, CHENG Y, SU Y, MINARY-JOLANDAN M, BAUGHMAN R H, QIAN D, LIU Z. Adv. Funct. Mater., 2019, 29(18):1808241.
71. [71]
  LENG X, ZHOU X, LIU J, XIAO Y, SUN J, LI Y, LIU Z. Mater. Horiz., 2021, 8(5):1538-1546.
1. [1]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128
2. [2]
  Xingchao Zhao , Xiaoming Li , Ming Liu , Zijin Zhao , Kaixuan Yang , Pengtian Liu , Haolan Zhang , Jintai Li , Xiaoling Ma , Qi Yao , Yanming Sun , Fujun Zhang . 倍增型全聚合物光电探测器及其在光电容积描记传感器上的应用. Acta Physico-Chimica Sinica, 2025, 41(1): 2311021-. doi: 10.3866/PKU.WHXB202311021
3. [3]
  Yuping Wei , Yiting Wang , Jialiang Jiang , Jinxuan Deng , Hong Zhang , Xiaofei Ma , Junjie Li . Interdisciplinary Teaching Practice——Flexible Wearable Electronic Skin for Low-Temperature Environments. University Chemistry, 2024, 39(10): 261-270. doi: 10.12461/PKU.DXHX202404007
4. [4]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
5. [5]
  Meiqing Yang , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-. doi: 10.3866/PKU.WHXB202310046
6. [6]
  Shuying Zhu , Shuting Wu , Ou Zheng . Improvement and Expansion of the Experiment for Determining the Rate Constant of the Saponification Reaction of Ethyl Acetate. University Chemistry, 2024, 39(4): 107-113. doi: 10.3866/PKU.DXHX202310117
7. [7]
  Heng Zhang . Determination of All Rate Constants in the Enzyme Catalyzed Reactions Based on Michaelis-Menten Mechanism. University Chemistry, 2024, 39(4): 395-400. doi: 10.3866/PKU.DXHX202310047
8. [8]
  Di Yang , Jiayi Wei , Hong Zhai , Xin Wang , Taiming Sun , Haole Song , Haiyan Wang . Rapid Detection of SARS-CoV-2 Using an Innovative “Magic Strip”. University Chemistry, 2024, 39(4): 373-381. doi: 10.3866/PKU.DXHX202312023
9. [9]
  Qilong Fang , Yiqi Li , Jiangyihui Sheng , Quan Yuan , Jie Tan . Magical Pesticide Residue Detection Test Strips: Aptamer-based Lateral Flow Test Strips for Organophosphorus Pesticide Detection. University Chemistry, 2024, 39(5): 80-89. doi: 10.3866/PKU.DXHX202310004
10. [10]
  Lisen Sun , Yongmei Hao , Zhen Huang , Yongmei Liu . Experimental Teaching Design for Viscosity Measurement Serves the Optimization of Operating Conditions for Kitchen Waste Treatment Equipment. University Chemistry, 2024, 39(2): 52-56. doi: 10.3866/PKU.DXHX202307063
11. [11]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
12. [12]
  Yang YANG , Pengcheng LI , Zhan SHU , Nengrong TU , Zonghua WANG . Plasmon-enhanced upconversion luminescence and application of molecular detection. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 877-884. doi: 10.11862/CJIC.20230440
13. [13]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
14. [14]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
15. [15]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
16. [16]
  Tongyu Zheng , Teng Li , Xiaoyu Han , Yupei Chai , Kexin Zhao , Quan Liu , Xiaohui Ji . A DIY pH Detection Agent Using Persimmon Extract for Acid-Base Discoloration Popularization Experiment. University Chemistry, 2024, 39(5): 27-36. doi: 10.3866/PKU.DXHX202309107
17. [17]
  Qin Tu , Anju Tao , Tongtong Ma , Jinyi Wang . Innovative Experimental Teaching of Escherichia coli Detection Based on Paper Chip. University Chemistry, 2024, 39(6): 271-277. doi: 10.3866/PKU.DXHX202309062
18. [18]
  Jinghan ZHANG , Guanying CHEN . Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2335-2355. doi: 10.11862/CJIC.20240249
19. [19]
  Naiying Fan , Chuanli Qin , Guo Zhang , Bin Wang , Yan Wang , Bing Zheng , Yichun Qu , Zhiyao Sun , Guanghui An . Case Design of Course Ideological and Political Education in Chemical Experiment Safety: the Safe Use of Common Laboratory Instruments and Glassware. University Chemistry, 2024, 39(2): 242-247. doi: 10.3866/PKU.DXHX202309061
20. [20]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002

Get Citation

PDF

XML

Metrics

PDF Downloads(23)
Abstract views(1037)
HTML views(75)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142