Citation: LIN Bing-Yong, WANG Yue-Liang, LIN Zhen-Yu, GUO Long-Hua. Fabrication and Application of Noble Metal Nanocomposites-Based Surface-Enhanced Raman Scattering Active Substrate[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(5): 653-665. doi: 10.19756/j.issn.0253-3820.210897 shu

Fabrication and Application of Noble Metal Nanocomposites-Based Surface-Enhanced Raman Scattering Active Substrate

1.
Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China;
2.
Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, China

Corresponding author: WANG Yue-Liang, GUO Long-Hua,
Received Date: 20 December 2021
Revised Date: 12 February 2022

Fund Project: Supported by the National Natural Science Foundation of China (No.22074054), the Key Research and Development Program of Zhejiang Province, China (No.2020C02022), the Nature Sciences Funding of Zhejiang Province, China (Nos.Q20B050002,LQ20B05004) and the Special Support Plan for High-level Talents in Zhejiang Province, China (No.2021R52044).

With the rapid development of nanotechnology and laser technology, surface-enhanced Raman scattering (SERS) technology has flourished with a great leap. As an analysis and detection technology for fast, nondestructive, and ultra-sensitive response to the fingerprint information of the target molecule, SERS technology has been widely applied in the field of food detection, environmental monitoring and clinical diagnosis. Fabrication of SERS substrate is the committed step of achieving the ultra-sensitive detection in various fields using SERS technology. At present, the SERS activity, homogeneity, and other properties of SERS substrates which are constructed by single noble metal nanomaterials through complex and time-consuming methods cannot fit the demand of the point-of-care detection in various fields. Therefore, more and more research scholars focus on the development of simple and rapid methods to fabrication of multi-functional composite SERS substrates and application of these composite SERS substrates into the field of food detection, environmental monitoring and clinical diagnosis. This article mainly reviews the preparation of precious metal composite SERS substrates and their applications in the past years, discusses and analyzes the function and application advantages of multi-functional composite SERS substrates. The forecast of multi-functional composite SERS substrate is also provided at the end of this article.
- Composite surface-enhanced Raman scattering substrate,
- Noble metal nanoparticles,
- Composite materials,
- Analytical applications,
- Review
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