Citation: WANG Xue-Mei, ZHAO Sui-Xin, LI Hai-Yin, LI Feng. Target-controlled In-Situ Formation of Quantum Dots for Fluorescence Sensing of Methidathion[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(3): 375-383. doi: 10.19756/j.issn.0253-3820.210847 shu

Target-controlled In-Situ Formation of Quantum Dots for Fluorescence Sensing of Methidathion

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

Corresponding author: LI Hai-Yin, LI Feng,
Received Date: 18 November 2021
Revised Date: 9 December 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21775082, 22076090).

A highly sensitive and reliable fluorescence sensor for detection of organophosphorus pesticide (OP) based on target-controlled in-situ formation of sadmium sulfide quantum dots (CdS QDs) was developed. Acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine (ATCh) into thiocholine (TCh), which acted as stabilizing agent to induce the formation of CdS QDs, subsequently improving the emission intensity. Whereas, upon the addition of target methidathion (Met), AChE activity was depressed and thus was not capable of catalyzing hydrolysis of ATCh into TCh. In this context, CdS QDs were not formed and the emission intensity of detection solution was not enhanced, justifying the close relationship between fluorescence signal and Met concentration. Therefore, highly sensitive analysis of Met was achieved on the basis of change in fluorescence emission with a limit of detection of 0.024 ng/mL (S/N=3). Furthermore, the developed fluorescence sensor was successfully employed to detect Met in extract solution of rice with recoveries of 96.7%-102.4%. Overall, the CdS QDs-based sensor presented a new thinking way to highly sensitive and reliable analysis of OPs, favoring OPs-related food safety.
- Sadmium sulfide quantum dots,
- Organophosphorus pesticide,
- Methidathion,
- Acetylcholinesterase,
- Fluorescence sensor
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