Citation: CAO Cheng-Cheng, LIN Xiang-Fang, REN Chen-Yu, SU Lei. Polyadenine-capped Gold Nanoclusters Incorporated into Zeolitic Imidazolate Framework-8 with Aggregation-induced Fluorescence Emission Enhancement for High-Sensitivity Fluorescence Detection of Ascorbic Acid[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(6): 932-939. doi: 10.19756/j.issn.0253-3820.210807 shu

Polyadenine-capped Gold Nanoclusters Incorporated into Zeolitic Imidazolate Framework-8 with Aggregation-induced Fluorescence Emission Enhancement for High-Sensitivity Fluorescence Detection of Ascorbic Acid

School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China

Corresponding author: SU Lei, sulei@szu.edu.cn
Received Date: 24 October 2021
Revised Date: 30 March 2022

Nano metal organic frameworks(NMOFs) have been widely used in biological diagnosis and treatment systems. In this work, a fluorescence analysis method based on gold nanoclusters(AuNCs) and metal organic framework zeolitic imidazolate framework-8(ZIF-8) composite materials was established for high-sensitivity detection of ascorbic acid(AA). The obtained nanocomposite material(AuNCs@ZIF-8) through the confinement effect of MOF(ZIF-8) showed aggregation-induced emission(AIE) enhancement.When AA was combined with ZIF-8, the framework of the composite material was destroyed, and the fluorescence intensity was greatly reduced due to the transition of AuNCs from the aggregate state to the dispersed state. The linear range of AA detection was measured to be 10-100 μmol/L, and the limit of detection(LOD, S/N=3) was 0.3 μmol/L This method could complete the detection of AA within 2 minutes,showing high selectivity for AA detection. This method was used to detect AA in human serum with good results, and the recoveries were 95.7%-100.9%.
- Zeolitic imidazolate framework-8,
- Gold nanoclusters,
- Fluorescence detection,
- Ascorbic acid
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