Citation: ZENG Hong-Da, DU Xiao-Xia, PAN Jia-Kai, WANG Yi-Fei, CHEN Zhen-Cheng, LI Hua. Study on High-field Asymmetric Waveform Ion Mobility Spectrometry System Using Inert Gas to Enhance Discharge of Hollow Needle-Ring Ion Source[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(5): 680-691. doi: 10.19756/j.issn.0253-3820.210750 shu

Study on High-field Asymmetric Waveform Ion Mobility Spectrometry System Using Inert Gas to Enhance Discharge of Hollow Needle-Ring Ion Source

Key Laboratory of Biomedical Sensors and Intelligent Instruments in Guangxi Universities, School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China

Corresponding author: LI Hua, lihua@guet.edu.cn
Received Date: 16 September 2021
Revised Date: 3 January 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos.62163009, 61864001) and the Natural Science Foundation of Guangxi, China (No.2021JJD170019).

Resolving power and sensitivity are two important parameters to characterize the performance of high field asymmetric waveform ion mobility spectrometry (FAIMS). To simultaneously improve the resolving power and sensitivity of flat plate FAIMS, a hollow needle-ring ion source for inert gas enhanced discharge is proposed in this work. At standard atmospheric pressure, inert gases helium and argon are introduced into the needle-ring ion source to improve the ionization efficiency of the ion source and achieve effective ionization of VOCs. Helium and argon gas with gas flow rates of 0.2, 0.3 and 0.4 L/min were added at a nitrogen flow rate of 1.8 L/min and a radio frequency voltage (RF) of 300 V, respectively. Compared with pure nitrogen, the signal intensities of acetone, ethanol and ethyl acetate were increased by 19.07, 17.26 and 10.85 times, respectively, after passing helium, and 4.86, 13.37 and 4.63 times, respectively, after passing argon, and the mixture of helium, argon and nitrogen resulted in multiple ion peaks in the FAIMS spectrum. The results showed that both helium and argon could improve both resolving power and sensitivity, and that helium was more effective than argon. Mass spectrometry experiments and penning ionization theory analysis showed that the main ions produced by ionization were monomeric and dimeric ions. This study provided new ideas and methods to improve the resolving power and sensitivity of FAIMS systems.
- High-field asymmetric waveform ion mobility spectrometry,
- Inert gas,
- Mass spectrometry,
- Resolving power,
- Sensitivity
1. [1]
  HERNÁNDEZ M M, ROPARTZ D, GARCÍA A M, ROGNIAUX H, DERVILLY P G, BIZEC B L. Molecules, 2019, 24(15):2706.
2. [2]
  MILLER R A, NAZAROV E G, EICEMAN G A, THOMAS KING A. Sens. Actuators, A, 2001, 91(3):301-312.
3. [3]
4. [4]
5. [5]
6. [6]
  COSTANZO M T, BOOCK J J, KEMPERMAN R H, WEI M S, YOST R A. Int. J. Mass Spectrom., 2016, 422:188-196.
7. [7]
  ARASARADNAM R P, MCFARLANE M, DAULTON E, SKINNER J, COVINGTON J. Dig. Liver Dis., 2016, 48(2):148-153.
8. [8]
  SUN T, HE J, QIAN S, ZHENG Y, ZHANG K, LUO J, TIAN F. Sens. Actuators, B, 2020, 320:128595.
9. [9]
  SANTIAGO B G, HARRIS R A, ISENBERG S L, RIDGEWAY M E, PILO A L, KAPLAN D A, GLISH G L. J. Am. Soc. Mass Spectrom., 2015, 26(10):1746-1753.
10. [10]
  WANG H W, CHEN C L, LIU Y J, ZHANG X T, KONG D Y, WANG X Z, LUO J K. Anal. Methods, 2015, 7(4):1401-1406.
11. [11]
  SHVARTSBURG A A, DANIELSON W F, SMITH R D. Anal. Chem., 2010, 82(6):2456-2462.
12. [12]
  SHVARTSBURG A A, SMITH R D. Anal. Chem., 2011, 83(1):23-29.
13. [13]
  SHVARTSBURG A A, IBRAHIM Y M, SMITH R D. J. Am. Soc. Mass Spectrom., 2014, 25(3):480-489.
14. [14]
  KUKLYA A, ENGELHARD C, KERPEN K, TELGHEDER U. J. Anal. At. Spectrom., 2016, 31(8):1574-1581.
15. [15]
  SANTIAGO B G, HARRIS R A, ISENBERG S L, GLISH G L. Analyst, 2015, 140(20):6871-6878.
16. [16]
  SHVARTSBURG A A, SMITH R D. Anal. Chem., 2011, 83(23):9159-9166.
17. [17]
  BARNETT D A, PURVES R W, ELLS B, GUEVREMONT R. J. Mass Spectrom., 2000, 35(8):976-980.
18. [18]
19. [19]
20. [20]
  WANG H, LIU Y J, LI S, WANG X Z, DENG J Y, CHEN C L. Int. J. Mass Spectrom., 2019, 442:7-13.
21. [21]
  KUKLYA A, REINECKE T, UTESCHIL F, KERPEN K, ZIMMERMANN S, TELGHEDER U. Talanta, 2017, 162:159-166.
22. [22]
23. [23]
24. [24]
  PURVES R W, BARNETT D A, ELLS B, GUEVREMONT R. J. Am. Soc. Mass Spectrom., 2001, 12(8):894-901.
25. [25]
  KARPAS Z, EICEMAN G A, KRYLOV E V, KRYLOVA N. Int. J. Ion Mobility Spectrom., 2006, 7(1):C8-C18.
26. [26]
  SHVARTSBURG A A, DANIELSON W F, SMITH R D. Anal Chem., 2010, 82:2456-2462.
27. [27]
  KRYLOV E V, NAZAROV E G, MILLER R A. Int. J. Mass Spectrom., 2007, 266(1-3):76-85.
28. [28]
  HIRAOKA K, FUJIMAKI S, KAMBARA S, FURUYA H, OKAZAKI S. Rapid Commun. Mass Spectrom., 2004, 18(19):2323-2330.
29. [29]
  HIRAOKA K, FURUYA H, KAMBARA S, SUZUKI S, HASHIMOTO Y, TAKAMIZAWA A. Rapid Commun. Mass Spectrom., 2006, 20(21):3213-3222.
30. [30]
  ANDRADE F J, SHELLEY J T, WETZEL W C, WEBB M R, GAMEZ G, RAY S J, HIEFTJE G M. Anal. Chem., 2008, 80(8):2646-2653.
31. [31]
  DZIDIC I, CARROLL D I, STILLWELL R N, HORNING E C. Anal. Chem., 2002, 48(12):1763-1768.
32. [32]
  HORNING E C, CARROLL D I, DZIDIC I, HAEGELE K D, HORNING M G, STILLWELL R N. J. Chromatogr. Sci., 1974, 12(11):725-729.
33. [33]
  KAMBARA H, MITSUI Y, KANOMATA I. Anal. Chem., 1979, 51(9):1447-1452.
34. [34]
  WEI M S, KEMPERMAN R H, YOST R A. J. Am. Soc. Mass Spectrom., 2019, 30(5):731-742.
35. [35]
  RORRER L C, YOST R A. Int. J. Mass Spectrom., 2015, 378:336-346.
36. [36]
  RUOTOLO B T, MCLEAN J A, GILLIG K J, RUSSELL D H. J. Mass Spectrom., 2004, 39(4):361-367.
37. [37]
  ZENG Y, TANG F, ZHAI Y D, WANG X H. Rev. Sci. Instrum., 2017, 88(9):1-10.
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