Citation: CANG Huai-Wen, LI Hang, HUANG Wei, ZHANG Yuan-Zhi, LI Jing-Hua, WANG Wei-Guo, LI Hai-Yang. Improving Performance of Ion Mobility Spectrometry Using Bradbury-Nielsen Ion Gate Pulse Waveform Modulation[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(12): 2067-2074. doi: 10.19756/j.issn.0253-3820.210684 shu

Improving Performance of Ion Mobility Spectrometry Using Bradbury-Nielsen Ion Gate Pulse Waveform Modulation

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Key Laboratory for Online Analytical Instrumentation, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Corresponding author: WANG Wei-Guo, LI Hai-Yang,
Received Date: 17 August 2021
Revised Date: 30 September 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22027804, 91961124) and the Foundation of Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Nos. DICPI201951, DICP ZZBS201701).

Ion mobility spectrometry (IMS) has been widely used in the field of detecting explosives, chemical agents and environmental pollutants due to the advantages such as high sensitivity, fast response ability and portability. How to improve the sensitivity and resolution of IMS has always been a research hot spot. The sensitivity and resolution are closely related to the characteristics of the initial ion current that is controlled by the voltage waveform applied to the ion gate. In this work, the voltage waveforms of different Bradbury-Nielsen (BN) ion gates were simulated by SIMION software. It was found that the performances of IMS including the sensitivity and resolution could be improved by adjusting the voltage waveform. The homemade research platform of IMS was built, and the effects of switching pulse waveform time (Δt₁), pulse voltage width (GPW) and pulse voltage difference (GVD) on the signal intensity and resolution of IMS were systematically investigated. The results showed that when GPW=80 μs, the acetone ion RIP intensity was increased by 3 times and the resolution was increased by 13%. When detecting dimethyl methylphosphate (DMMP) sample (5.8 μg/L), the ion intensities of (Ac)₂H⁺, (Ac)(DMMP) H⁺ and (DMMP)₂H⁺ were increased by 81%, 156% and 260%, respectively. Meanwhile, the signal-to-noise ratio of (Ac)(DMMP) H⁺ was increased by 2.5 times and that of (DMMP)₂H⁺ was increased by 3 times. The results were helpful to develop high resolution ion mobility spectrometer.
- Drift time ion mobility spectrometry,
- Switching pulse square wave,
- Bradbury-Nielsen gate
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