Citation: LI Meng, LU Xi-Cheng, HUANG Yun-Yan, KANG Jia-Xin, WEI Zi-Kai, REN Hao-Wei, LIU Ning. Differential Analysis of Goat Milk at Different Latitudes Based on Metabolomics Technology[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(11): 1864-1872. doi: 10.19756/j.issn.0253-3820.210497 shu

Differential Analysis of Goat Milk at Different Latitudes Based on Metabolomics Technology

LI Meng ^1,2 ,
LU Xi-Cheng ^1,2 ,
HUANG Yun-Yan ² ,
KANG Jia-Xin ^1,2 ,
WEI Zi-Kai ^1,2 ,
REN Hao-Wei ^1,2 ,
LIU Ning ^1,2,,

1.
Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China;
2.
College of Food Science, Northeast Agricultural University, Harbin 150030, China

Corresponding author: LIU Ning, ningliuneau@outlook.com
Received Date: 13 May 2021
Revised Date: 31 August 2021

Fund Project: Supported by the China National Key R&D Program during the 13th Five-year Plan Period (No.2018YFC160430401).

A non-targeted metabolomics study based on ultra-high performance liquid chromatography qexactive mass spectrometry (UHPLC-QE-MS) for investigation of the variability of metabolites of goat milk across latitudes from Heilongjiang, Gansu and Hunan province of China was performed. The expression trends of 22 differential metabolites were found to be positively correlated with latitude, and 15 differential metabolites were found to be negatively correlated with latitude. The types of differential metabolites whose expression was up-regulated with increasing latitude included glycerophospholipids and sphingolipids. The types of down-regulated differential metabolites included organosulfides, amino acids, organic heterocyclic compounds, alcohols, phenols, organic oxides and organic acids and their derivatives. Metabolic pathway analysis of the differentially expressed metabolites showed that a total of 6 metabolic pathways were involved in the up-regulated differentially expressed metabolites and 7 metabolic pathways were involved in the down-regulated differentially expressed metabolites. This study further mapped the correlation analysis of key metabolic pathways and analyzed the mechanism of interactions between metabolic pathways. This study provided a new perspective to further investigate the influencing factors of sheep milk composition.
- Metabolomics,
- Latitude,
- Goat,
- Milk,
- Metabolites
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