Citation: CUI Lin, WANG Peng-Yu, WANG Cheng-Ming, ZHANG Chun-Yang. Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(5): 665-675. doi: 10.19756/j.issn.0253-3820.201722 shu

Advance in Applications of Organic Polymer-based Electrochemiluminescence in Biochemical Analysis

College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Corresponding author: ZHANG Chun-Yang, cyzhang@sdnu.edu.cn
Received Date: 3 December 2020
Revised Date: 26 February 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21735003, 21527811, 21605096, 21974080).

Electrochemiluminescence (ECL) is the process of producing species on the surface of electrodes and the subsequent formation of excited luminescence through electron transfer reaction. Organic polymeric materials are constructed by one or more molecules/molecular groups (structural units or monomers) which are covalently bonded to form multiple repeating monomer units. Organic polymers include metal-organic frameworks (MOFs), metal-organic gels (MOGs), conjugated microporous polymers (CMPs) and polymer dots (Pdots). In comparison with the cadmium-containing quantum dots, organic polymer materials have significant advantages including low toxicity and good biocompatibility, and they not only function as the ECL emitter, but also enhance the ECL signal. The organic polymer-based ECL sensors are characterized by good selectivity, high specificity, simple equipment, stable signal, easy measurement, high sensitivity, wide dynamic range, and low background, and they are widely applied to environmental monitoring, immunoassay, and nucleic acids analysis. This review summarizes the recent advance in applications of organic polymer-based ECL sensors in biochemical analysis, and focuses on the selective detection of metal ions, small biological molecules, nucleic acids, and proteins. In addition, we highlight the challenges and trends in the development of organic polymer-based ECL sensors.
- Organic polymer,
- Electrochemiluminescence,
- Biosensors,
- Bioanalysis,
- Review
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