Citation: WANG Chao, JIA Xiao-Dan, JIANG Xiu-E. Application of Nanomaterials in Bioimaging Guided Photodynamic Therapy[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1142-1153. doi: 10.19756/j.issn.0253-3820.201702 shu

Application of Nanomaterials in Bioimaging Guided Photodynamic Therapy

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: JIANG Xiu-E, jiangxiue@ciac.ac.cn
Received Date: 24 November 2020
Revised Date: 17 March 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22025406, 21874125, 21877107).

With the development of nanotechnology, developing novel nanoplatforms simultaneously integrating bioimaging and treatment for precise cancer theranostics has become a research hotspot. As one of the emerging therapies, photodynamic therapy (PDT) has many advantages such as high specificity, controllability and low side effects, which has attracted extensive research attention. Recently, PDT based on nanomaterials has overcome the limitations of traditional PDT such as low stability, low tumor-targeting ability and phototoxicity, and has shown great application potential. Furthermore, the technologies of bioimaging and PDT can be integrated into a single nanoplatform to realize cancer theranostics. So far, a variety of imaging modes have been applied to the research of PDT based on nanomaterials, such as fluorescence imaging, magnetic resonance imaging (MRI), computer tomography (CT) imaging, ultrasound (US) imaging, photoacoustic (PA) imaging, positron emission tomography (PET) imaging, and single-photon emission computed tomography (SPECT) imaging. This article summarizes the use of multifunctional nanomaterials for bioimaging-guided PDT. Finally, the current challenges and prospects for future development are discussed.
- Nanomaterials,
- Photodynamic therapy,
- Bioimaging,
- Tumor,
- Theranostics,
- Review
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