Citation: CHEN Wen-Yong, WANG Jian-Hua, YANG Tian-Tian, HUO Geng-Yang, XU Wei, LI Bin, ZHOU Xing-Fei. Self-assembly of Aβ16-22 in Water Nanofilm on Mica Surface[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(4): 611-617. doi: 10.19756/j.issn.0253-3820.201696 shu

Self-assembly of Aβ16-22 in Water Nanofilm on Mica Surface

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School of Physics Science and Technology, Ningbo University, Ningbo 315211, China;
2.
Basic Cross-research Center, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China

Corresponding author: ZHOU Xing-Fei, zhouxingfei@nbu.edu.cn
Received Date: 23 November 2020
Revised Date: 20 January 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.31670871, 12074208), the Natural Science Foundation of Zhejiang Province, China (No.LY18A040003) and the Natural Science Foundation of Ningbo, China (No.2018A610220).

The self-assembly of amyloid peptides in crowded environment has attracted tremendous attention due to its close relation to human neurological diseases. The experiments investigated the aggregation and diffusion behavior of Aβ16-22 in the water nanofilm adsorbed on the surface of mica substrate under a closed environment. The result showed that the peptide molecules could diffuse and aggregate in water layer and formed peptide nanosheets with different heights under various conditions, and the nanosheet formation was remarkably affected by the incubation temperature and peptide concentration. The elastic modulus of Aβ16-22 nanosheets was further evaluated by PeakForce-QNM, and it was found that the elastic modulus were estimated to be about (5.0±0.4) GPa, notably stiffer than that of amyloid fibrils ((3.1±0.2) GPa) formed in bulk solution. NanoIR analysis indicated that the secondary structure of nanosheets adsorbed on mica surface was mainly related to α-helix conformations, unlike the β-sheet structure of amyloid fibrils. We attributed the discrepancy of compression elasticity to the difference of peptide second structure of these two species.
- Water nanofilm,
- Amyloid peptides,
- Nanosheets,
- Elastic modulus
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沈阳化工大学材料科学与工程学院沈阳 110142