Citation: TAO Tian, YE Song, MA Ming-Yu, GAO Nan, CAI Zhi-Wei, LIU Xu, CHANG Gang, HE Yun-Bin. Highly Sensitive Detection of Glucose Using Solution-gated Graphene Transistor Based on Copper-Metal Organic Framework[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(3): 387-396. doi: 10.19756/j.issn.0253-3820.201594 shu

Highly Sensitive Detection of Glucose Using Solution-gated Graphene Transistor Based on Copper-Metal Organic Framework

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China

Corresponding author: CHANG Gang, HE Yun-Bin,
Received Date: 9 October 2020
Revised Date: 6 January 2021

Fund Project: National Natural Science Foundation of China (Nos. 51672074, 11774082, 11975093), the Natural Science Foundation of Hubei Province, China (No. 2019CFA006) and the Wuhan Application Foundation Frontier Project (No. 201801041011287).

A novel nonenzymatic glucose sensor based on solution-gated graphene transistor (SGGT) was constructed by combining the good electrocatalytic activity of metal organic framework (MOF) materials with the signal amplification of SGGT in sensing. With trimesic acid (BTC) as the organic ligands, copper-based MOF materials (Cu-BTC) were synthesized by solvothermal method and fixed on the glassy carbon electrode with Nafion film as the gate of the device. Monolayer graphene acted as the channel of transistor. The sensing mechanism was attributed to the change of effective gate voltage applied to SGGT induced by the electrochemical reactions of glucose at the Cu-BTC modified gate electrode, thus changing the channel carrier concentration and the channel current. Due to the good electrocatalytic activity of Cu-BTC for glucose and the high sensitivity of SGGT, the SGGT sensor modified with Cu-BTC exhibited excellent sensing performance for glucose with detection limit of as low as 1 nmol/L and linear range from 1 nmol/L to 40 mmol/L, which was superior to most of the traditional glucose detection methods. Moreover, the device exhibited a good anti-interference to the main components in sweat and blood, and showed good time stability in long-term repetitive experiments. Finally, the device was successfully applied to detection of glucose in human sweat. The SGGT sensor modified with Cu-BTC was expected to be applied to non-enzyme and non-invasive detection of glucose in the realm of diabetes treatment and monitoring.
- Metal organic framework,
- Copper,
- Solution-gated graphene transistor,
- Glucose,
- Enzyme-free sensing,
- Non-invasive detection
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