Citation: KUANG Jing-Jing, KANG Lu, LIN Chu-Hui, WANG Yue-Rong, ZHANG Min, ZHANG Hong-Yang, Hu Ping. Separation and Detection of Exosomes Based on Microfluidic Chip[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(9): 1437-1450. doi: 10.19756/j.issn.0253-3820.201568 shu

Separation and Detection of Exosomes Based on Microfluidic Chip

1.
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;
2.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Hu Ping, huping@ecust.edu.cn
Received Date: 21 September 2020
Revised Date: 26 June 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.81973285).

As the smallest extracellular vesicles, exosomes contain lipids, proteins, mRNA, microRNA and double-stranded DNA, which can be secreted by most cells and circulated in body fluids and are involved in intercellular communication. In recent years, it has been found that exosomes play an extremely important role in tumorigenesis, migration and growth, tissue damage repair, immune antigen presentation and neurodegenerative diseases. Exosomes can be used as biomarker for diagnosis of related diseases. Therefore, it is of great importance to study the separation and detection technology for exosomes. This review summarizes the methods of separation and detection of exosomes based on microfluidic chip.
- Exosomes,
- Microfluidic chip,
- Separation,
- Detection,
- Review
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