Citation: CHEN Feng-Ming, ZHANG Feng, GAO Fei, YONG Wei, YANG Min-Li, FENG Feng. Thermal Desorption-Cooled Injection System-Gas Chromatography-Mass Spectrometry for Simultaneous Determination of Seven Kinds of Alkaloids and Nine Kinds of Flavor Compounds in Cigarette[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(1): 128-136. doi: 10.19756/j.issn.0253-3820.201555 shu

Thermal Desorption-Cooled Injection System-Gas Chromatography-Mass Spectrometry for Simultaneous Determination of Seven Kinds of Alkaloids and Nine Kinds of Flavor Compounds in Cigarette

Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China

Corresponding author: ZHANG Feng, fengzhang@126.com
Received Date: 14 September 2020
Revised Date: 3 November 2020

Fund Project: Supported by the Central Public-Interest Scientific Institution Basal Research Fund (No.2018JK001).

A novel method for determination of seven kinds of alkaloids (isoquinoline, nicotine, 3-(2-pyrrolidinyl) plridine nornicotine, myosmine, b-nicotyrine, Anabasine, 2,3'-bipyridine, and anabaseine) and nine kinds of flavor compounds (hydrocoumarin, vanillin, coumadin, ethyl vanillin, methyl vanillin, 7-methyl coumarin, 7-methoxycoumarin, 7-ethoxy-4-methylcoumarin, and pyranocoumarin) in cigarette by thermal desorption-cooled injection system coupled with gas chromatography-mass spectrometry (TDU-CIS-GC-MS) was developed. By optimizing the conditions such as TDU (time, temperature, and flow rate of helium gas), CIS temperature, vent time and purge time, the cigarette alkaloid compound could be completely thermal desorption, and the volatile alkaloids and coumarin substances were enriched using the cold injection system. A DB-5 MS chromatographic column was used for separation, and a matrix curve external label method was used to quantify the matrix effect under the selected ion monitoring mode (SIM). The results showed that the linear range of 7 kinds of alkaloids and 9 kinds of flavors was 1-500 μg/L, the linear correlation coefficient (R²) was greater than 0.993, and the limits of detection (LOD) and limits of quantitation (LOQ) were 0.02-0.50 μg/kg and 0.1-2.0 μg/kg, respectively. This method was simple, safe with high sensitivity and accuracy, and suitable for the determination of alkaloids and flavor compounds in cigarette, which was very important for the analysis of complex volatile trace substances in heated non-burning cigarette.
- Thermal desorption,
- Cooled injection system,
- Gas chromatography-mass spectrometry,
- Alkaloid,
- Flavor
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