Citation: LU Xian-Lin, HE Wei. Research Advances in Excited State Intramolecular Proton Transfer Fluorescent Probes Based on Combined Fluorescence Mechanism[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(2): 184-196. doi: 10.19756/j.issn.0253-3820.201512 shu

Research Advances in Excited State Intramolecular Proton Transfer Fluorescent Probes Based on Combined Fluorescence Mechanism

LU Xian-Lin ,
HE Wei ^,

School of Pharmacy, Air Force Medical University, Xi'an 710032, China

Corresponding author: HE Wei, weihechem@fmmu.edu.cn
Received Date: 24 August 2020
Revised Date: 2 November 2020

Fund Project: Supported by the Shaanxi Province Key Research and Development Program (No. S2019ZDLSF03-03) and the National Science and Technology Major Project of China on "Key New Drug Creation and Development Program" (No.2014ZX09J14104-06C).

Fluorescent probes can achieve rapid detection of analytes, and have become a research hotspot in recent years due to their excellent selectivity, high sensitivity and easy operation. Excited state intramolecular proton transfer (ESIPT) is one of the most basic strategies for designing fluorescence probes. Fluorescent probes based on ESIPT possess large Stokes shift, strong luminescence and high fluorescence quantum yield. However, there are still some disadvantages, such as sensitivity to the environment and short emission wavelength. In recent years, the combination of ESIPT with other fluorescence mechanisms has obtained new fluorescent probes with dual mechanism of fluorescence response. This strategy can not only solve the shortage of ESIPT fluorophore, but also realize multi-fluorescence signal channel, and significantly improves the selectivity and sensitivity of the new probe. In this review, we mainly analyze the detection mechanism and imaging application of fluorescence probes of photoinduced electron transfer (PET)-ESIPT, intramolecular charge transfer (ICT)-ESIPT, fluorescence resonance energy transfer (FRET)-ESIPT, aggregation-induced emission (AIE)-ESIPT for ions, small molecules, biological macromolecules in recent years.
- Fluorescence probe,
- Combined fluorescence mechanism,
- Excited state intramolecular proton transfer,
- Review
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