Citation: ZHANG Pan, JIANG Li-Yan, MA Jiu-Tong, JIA Qiong. Application of Molecular Imprinting Technology in Post-translational Modified Protein Enrichment[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(1): 24-33. doi: 10.19756/j.issn.0253-3820.201369 shu

Application of Molecular Imprinting Technology in Post-translational Modified Protein Enrichment

ZHANG Pan ¹ ,
JIANG Li-Yan ² ,
MA Jiu-Tong ^1,, ,
JIA Qiong ^1,,

1.
College of Chemistry, Jilin University, Changchun 130012, China;
2.
College of Life Sciences, Jilin University, Changchun 130012, China

Corresponding author: MA Jiu-Tong, JIA Qiong,
Received Date: 25 June 2020
Revised Date: 26 September 2020

Fund Project: .

Post-translational modification of proteins plays an important regulatory role in the process of cell life, enabling proteins to have biological activities and perform corresponding functions. The content of post-translational modification proteins in the organism is very low, which makes it commit to a mighty challenge to accurately identify the post-translational modification proteins. The molecularly imprinted cavity, which is perfectly matched with the size, shape and functional groups of the target molecules, has shown great potential in the separation of modified proteins. In this paper, the types and characteristics of post-translational modified proteins and molecular imprinting methods are summarized. On this basis, the application of molecularly imprinted polymers in the enrichment of post-translational modified proteins is reviewed, and the prospect of its development is prospected.
- Molecular imprinting technology,
- Protein,
- Post-translational modification,
- Enrichment,
- Review
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