Citation: LI Nian-Sheng, CHEN Li, XIAO Zuo-Xiu, YANG Yu-Qi, AI Ke-Long. Progress in Detection of Biomarker of Ovarian Cancer: Lysophosphatidic Acid[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(12): 1597-1606. doi: 10.19756/j.issn.0253-3820.201339 shu

Progress in Detection of Biomarker of Ovarian Cancer: Lysophosphatidic Acid

Xiangya School of Pharmaceutical Sciences, Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha 410078, China

Corresponding author: AI Ke-Long, aikelong@csu.edu.cn
Received Date: 20 June 2020
Revised Date: 14 August 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (No.21974134) and the Innovation-Driven Project of Central South University, China (No. 202045005).

Ovarian cancer is a serious threat to women's health, and its mortality rate is the highest in gynecological cancer. At present, there is a lack of effective and convenient early diagnosis technology for ovarian cancer. Most of the patients with ovarian cancer are found in the middle and late stage and miss the best time for treatment. Therefore, the rapid, sensitive, economic, and accurate detection of early ovarian cancer is of great significance. In recent years, lysophosphatidic acid (LPA) has been found to increase in serum in the early stage of ovarian cancer, but less in other diseases. Therefore, LPA is a promising and highly specific marker of ovarian cancer. To detect LPA, many detection techniques and methods have been developed. In recent years, great progress has been made in this field. This paper summarizes the detection methods of LPA, and focuses on the important progress in this field in recent years. Finally, the challenges and prospects of LPA detection in real clinical application are also prospected.
- Ovarian cancer,
- Lysophosphatidic acid,
- Biomarker,
- Mass spectrometry,
- Colorimetry,
- Fluorescence detection,
- Review
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