Citation: YANG Jie-Wei, WANG Chen-Yu, LUO Li, GUO Lei, XIE Jian-Wei. Applications and Prospects of Oligonucleotide Aptamers in Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(11): 1439-1447. doi: 10.19756/j.issn.0253-3820.201285 shu

Applications and Prospects of Oligonucleotide Aptamers in Mass Spectrometry

YANG Jie-Wei ¹ ,
WANG Chen-Yu ^1,2 ,
LUO Li ^1,3 ,
GUO Lei ^1,, ,
XIE Jian-Wei ¹

1.
State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, China;
2.
College of Pharmacy, Minzu University of China, Beijing 100081, China;
3.
School of Public Health, Hebei Medical University, Shijiazhuang 050017, China

Corresponding author: GUO Lei, guolei@bmi.ac.cn
Received Date: 19 May 2020
Revised Date: 19 August 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (No.21974152).

Oligonucleotide aptamers are an important kind of chemical antibody-like functional biomolecules. The aptamer-based mass spectrometric techniques can not only provide molecular mass and characteristic structures by mass spectrometry, but show high sensitivity and high affinity enrichment towards target molecules by aptamers. This review summarized the advances in the aptamer-based mass spectrometric applications, highlighted the progress of aptamer-target interaction characterization, as well as the applications of aptamer as off-line or on-line affinity materials in mass spectrometric techniques. It suggested that the combination of various new mass spectrometric techniques, the construction or combination of varied pretreatment or on-line signal amplification approaches, especially the applications of aptameric functional nanomaterials, should be focused in the aspects of interaction characterization, selective extraction and highly sensitive detection of trace target molecules. The future prospects of the development were also described.
- Aptamer,
- Mass spectrometry,
- Interaction characterization,
- Nanomaterials,
- Functionalization,
- Review
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