Citation: SHENG Nan, MA Xue-Ping, PANG Shu-Yun, SONG Qin-Xin, ZOU Bing-Jie, ZHOU Guo-Hua. Research Progress of Nucleic Acid Detection Technology Platforms for New Coronavirus SARS-CoV-2[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(10): 1279-1287. doi: 10.19756/j.issn.0253-3820.201259 shu

Research Progress of Nucleic Acid Detection Technology Platforms for New Coronavirus SARS-CoV-2

SHENG Nan ^1, ,
MA Xue-Ping ¹ ,
PANG Shu-Yun ¹ ,
SONG Qin-Xin ^1,2 ,
ZOU Bing-Jie ^1,3 ,
ZHOU Guo-Hua ^1,3,4

1.
Department of Pharmacology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China;
2.
Key Laboratory of Drug Quality Control and Pharmacovigilance of Ministry of Education, China Pharmaceutical University, Nanjing 210009, China;
3.
Department of Chemistry, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210093, China;
4.
The First School of Clinical Medicine, Southern Medical University, Nanjing 210002, China

Received Date: 6 May 2020
Revised Date: 6 August 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 61871403, 81703474, 81673390), the Jiangsu Provincial Medical Youth Talent Program (No. QNRC2016889) and the Natural Science Foundation of Jiangsu Province, China (No. BK20180292).

The new coronavirus SARS-CoV-2 has spread to the whole world, seriously threatening human life and disrupting people's lives. SARS-CoV-2 is a highly infectious virus with a long incubation period, encompassing asymptomatic infections. Therefore, accurate detection of SARS-CoV-2 is essential for the prevention and control of the epidemic. Currently, nucleic acid detection has played an important role in the prevention and control of SARS-CoV-2. A variety of nucleic acid detection technologies for SARS-CoV-2 have been developed, and some technologies have been converted into available kits for clinical detection. However, these technologies have different principles and detection platforms. How to choose the appropriate nucleic acid detection technology for SARS-CoV-2 perplexes epidemic prevention and control. Based on the latest research progress of nucleic acid technologies for SARS-CoV-2, this paper introduced the principles and technology platforms of these detection technologies, thoroughly compared the advantages and disadvantages of each technology and clarified the scope of applications, a reference was provided for selecting the appropriate nucleic acid detection technology for SARS-CoV-2. Furthermore, this paper provided a prospect for developing the technologies of detecting pathogens similar to SARS-CoV-2.
- SARS-CoV-2,
- Nucleic acid detection,
- Technical principle,
- Review
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