Citation: LIU Meng-Xuan, YIN Jian-Hang, MENG Lei, XU Na. One-step Synthesis of Polyethylenimine-Protected Fluorescent Silver Nanoclusters and Its Application in Detection of Metronidazole[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(11): 1556-1563. doi: 10.19756/j.issn.0253-3820.201257 shu

One-step Synthesis of Polyethylenimine-Protected Fluorescent Silver Nanoclusters and Its Application in Detection of Metronidazole

LIU Meng-Xuan ¹ ,
YIN Jian-Hang ² ,
MENG Lei ¹ ,
XU Na ^1,,

1.
College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China;
2.
College of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China

Corresponding author: XU Na, xn_1216@163.com
Received Date: 6 May 2020
Revised Date: 28 August 2020

Fund Project: This work was supported by the Project of Science and Technology Department of Jilin Province (No. 20180520006JH) and the Project of Education Department of Jilin Province, China (No. JJKH20200241JK).

Metronidazole (MNZ) of nitroimidazole antibiotics is a kind of antibiotic commonly used in many fields. It is mostly used to treat the infection caused by anaerobic bacteria or as an additive in animal feed. However, when MNZ remains in the human body in excess, it will lead to teratogenic, carcinogenic and other serious side effects. In this work, a novel fluorescent probe based on polyethylenimine stabilized silver nanoclusters (AgNCs@PEI) was successfully synthesized by one-step microwave method. The as-prepared AgNCs@PEI showed good fluorescence stability in a wide ion concentration range or after long time of illumination (at 455 nm for 30 min). The hydrogen bonds between amino functional groups of PEI ligand and N atoms of the imidazole ring of MNZ resulted in formation of a stable non-radiative ground state complex that caused the decrease of fluorescence intensity of the AgNCs. The results showed that the probe had good selectivity for MNZ, with a linear range of 0.1-200 mol/L and a detection limit of 0.038 mol/L. The fluorescent probe was applied to determination of MNZ in human urine samples with recoveries of 95.8%-103.4%, and the relative standard deviations were less than 4.3%, indicating the new fluorescence probe had potential application value in drug detection.
- Polyethylenimine,
- Silver nanoclusters,
- Metronidazole,
- Fluorescent probe
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