Citation: CUI Feng-Zhi, LIU Jian-Hua, LIU Yang, YUAN Bi-Ying, GONG Xue, YUAN Qing-Hai, GONG Ting-Ting, WANG Lei. Synthesis of PEGylated BaGdF₅ Nanoparticles as Efficient CT/MRI Dual-modal Contrast Agents for Gastrointestinal Tract Imaging[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(8): 1004-1011. doi: 10.19756/j.issn.0253-3820.201251 shu

Synthesis of PEGylated BaGdF₅ Nanoparticles as Efficient CT/MRI Dual-modal Contrast Agents for Gastrointestinal Tract Imaging

Department of Radiology, the Second Hospital of Jilin University, Changchun 130041, China

Received Date: 4 May 2020
Revised Date: 12 June 2020

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 81571737).

Molecular imaging (MI) techniques have extremely significant effect on the diagnosis and prognosis of diseases, such as gastrointestinal (GI) tract-related diseases. Furthermore, nanomaterials as contrast agents have attracted a great deal of research attention due to their rational fabrication and biomedical application. Herein, a facile process to synthesis PEGylated BaGdF₅ nanoparticles via a one-pot solvothermal route was reported as CT/MRI dual-modal contrast agents for in vivo imaging of GI tract. Compared to the commercially used iodine contrast agents, the well-prepared nanoparticles exhibited enhancement in computed tomography (CT) imaging. In the presence of Gd, nanoparticles could also be used in magnetic resonance imaging (MRI). PEGylated BaGdF₅ nanoparticles were characterized by transmission electron microscopy (TEM), X-ray powder diffraction analysis (XRD), Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA). Besides, MTT assay revealed that the obtained PEGylated BaGdF₅ nanoparticles proved to be low toxicity for Hela cells. Hemolytic assay illustrated that nanoparticles possessed favorable hemocompatibility. H & E histological staining assessed long-term toxicity of oral PEGylated BaGdF₅ nanoparticles and the results showed that nanoparticles had overall safety for GI tissue with comparatively high biocompatibility. PEGylated BaGdF₅ nanoparticles were admired multi-functional contrast agents to apply in CT and MRI imaging with prominent prospects.
- Computed tomography imaging,
- Magnetic resonance imaging,
- Nanoparticles,
- Contrast agents
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Synthesis of PEGylated BaGdF5 Nanoparticles as Efficient CT/MRI Dual-modal Contrast Agents for Gastrointestinal Tract Imaging

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通讯作者: 陈斌, bchen63@163.com

Synthesis of PEGylated BaGdF₅ Nanoparticles as Efficient CT/MRI Dual-modal Contrast Agents for Gastrointestinal Tract Imaging