Citation: GUO Cong, ZHU Zhong-Jie, SHEN Jian-Xiong, ZHANG Zong-Chang, ZHANG Jian-Bing, ZHAO De-Ming, ZHAO Hong-Wei. Broadband Terahertz Spectroscopy of Glutathione[J]. Chinese Journal of Analytical Chemistry, ;2020, 48(10): 1367-1374. doi: 10.19756/j.issn.0253-3820.201148 shu

Broadband Terahertz Spectroscopy of Glutathione

1.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China;
2.
Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China;
3.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

Received Date: 21 March 2020
Revised Date: 3 July 2020

Fund Project: This work was supported by the Main Direction Program of Knowledge Innovation and Open Project Program of Key Laboratory of Interfacial Physics and Technology of Chinese Academy of Sciences and the National Defense Science and Technology Innovation Special Zone.

The conformation of glutathione is of great significance for its biological function. In this study, the absorption spectra of reduced (GSH) and oxidized (GSSG) glutathione in the frequency range of 0.5-12 THz were obtained by the air plasma terahertz time-domain spectroscopy (THz-TDS). The results demonstrated that GSH had rich characteristic absorption peaks in the THz region, while GSSG presented a monotonous absorption spectrum without obvious peaks. Combined with powder X-ray diffraction (PXRD), GSH had a certain crystal structure and GSSG was amorphous, suggesting that the THz spectroscopy was sensitive to the molecular structure and crystal form. The density functional theory (DFT) calculation based on the GSH crystal structure was performed to simulate the THz absorption spectrum and analyze the vibrational property. The result showed that GSH molecule could form rich intra-and inter-molecular hydrogen bonds, which helped to constrain flexible peptide. Lattice vibration and hydrogen bonding of GSH can effectively resonate with THz waves. The different THz absorption peaks of GSH correspond to different collective or local molecular vibrations which were closely related to the hydrogen bonding interactions. The study may help to deepen the understanding of GSH molecular conformation and weak interactions.
- Broadband terahertz spectroscopy,
- Reduced glutathione,
- Oxidized glutathione,
- Low frequency vibration,
- Hydrogen bond
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1.
沈阳化工大学材料科学与工程学院沈阳 110142